Pain Control Associated with Carboxytherapy in Cellulite Patients

Pain Management associated with the application of Carboxytherapy in patients with Cellulite: randomized controlled trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

REBEC

Registry ID

RBR-8jcqy7c

Enrollment

Unknown

Registered

2021-08-25

Start date

2021-06-30

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carbon Dioxide

Interventions

The subjects will be randomly allocated to one of the three groups: Group of vibrating device A (n = 26), Group of vibrating device B (n = 26) and Control Group (n = 26). In Group A, the subjects will

in Group B, subjects will receive BlaineLabs® vibrating anesthesia during carboxytherapy

and in the control group, the subjects will receive only the carboxytherapy technique, according to the study flowchart, represented in Figure 1. The side of the buttock (right or left) that will rece

G01.374.930

Eligibility

Sex/Gender

Female

Age

18 Years to 49 Years

Inclusion criteria

Inclusion criteria: Women; age group between 18 and 49 years; body mass index from 18.5 to 39.9 kg / m²; no previous experience with carboxytherapy; with moderate or severe cellulitis in the gluteal region;.

Exclusion criteria

Exclusion criteria: Pregnant women; lactating women; in the post-menopausal period or amenorrhea; metabolic or autoimmune disorders; history of epilepsy; the presence of malignant or benign tumors; using diuretics; diagnosis of oncological, cardiac and autoimmune pathologies;

Design outcomes

Primary

Measure	Time frame
It is expected to evaluate the effect of the anesthetic vibration technique, on the intensity of pain associated with carboxitherapy for cellulite. Pain intensity will be assessed using the numerical pain scale (END). This consists of a numerical sequence of 11 points, ranging from 0 to 10, where 0 represents “no pain” and 10 represents “worst possible pain”. The assessment of pain intensity will be carried out at the end of each carboxytherapy puncture. Each quadrant will receive a maximum of two points and will be averaged per quadrant. At the end of the procedure, the mean of all quadrants will be considered. We will observe, based on the outcome of pain intensity, a difference of 1.7 points on the numerical pain scale between the intervention groups.	—

Measure

Time frame

It is expected to evaluate the effect of the anesthetic vibration technique, on the intensity of pain associated with carboxitherapy for cellulite. Pain intensity will be assessed using the numerical pain scale (END). This consists of a numerical sequence of 11 points, ranging from 0 to 10, where 0 represents “no pain” and 10 represents “worst possible pain”. The assessment of pain intensity will be carried out at the end of each carboxytherapy puncture. Each quadrant will receive a maximum of two points and will be averaged per quadrant. At the end of the procedure, the mean of all quadrants will be considered. We will observe, based on the outcome of pain intensity, a difference of 1.7 points on the numerical pain scale between the intervention groups.

—

Secondary

Measure	Time frame
Secondary outcomes are not expected	—

Countries

Brazil

Contacts

Public ContactAdria Sadala

adriasadala@yahoo.com.br+55-092-999040001

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 19, 2026