Knee osteoarthritis
Conditions
Interventions
50 patients will be randomly allocated to treatment sequence A: 12 weeks of homeopathy and physiotherapy, 4 weeks of physiotherapy and placebo washout and 12 weeks of placebo and physiotherapy.
50 pa
Drug
Other
E02.095.682
H02.010.625
E02.760.169.063.500.387
Sponsors
Unidade de Saúde Escola da Universidade Federal de São Carlos
Universidade Federal de São Carlos
Eligibility
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Women and men 50 to 75 years old with a knee osteoarthritis diagnosis (according to the American College of Rheumatology criteria) in at least one knee compartment (tibiofemoral and/or patellofemoral).
Exclusion criteria
Exclusion criteria: Grade 1 or 4 in Kellgren and Lawrence radiologic classification of osteoarthritis; other inflammatory chronic diseases with musculoskeletal impairment; regular use of duloxetine or similar; use of anti-inflammatory drugs. Analgesic scape medication will be allowed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In the group initially treated with homeopathy, we expect to find a 30% improvement of reported pain at week 12 (in relation to basal values), assessed through Visual Analog Scale for pain. | — |
Secondary
| Measure | Time frame |
|---|---|
| Compared to basal values, we expect to observe improvement in pain and mobility in all included patients at weeks 12 and 28. We also expect that that improvement will be significantly superior during homeopathy treatment periods, compared with placebo. Endpoints will be assessed by the following measures: Visual Analog Scale for pain; WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index); 40 meters fast paced walk test; Timed up and go test; 30 seconds chair-stand Test; analgesics load. Adverse Events will be registered throughout the entire study. | — |
Countries
Brazil
Contacts
Public ContactUbiratan Adler
Unidade de Saúde Escola da Universidade Federal de São Carlos
Outcome results
None listed