others interstitial lung disease with fibrosis
Conditions
Interventions
Observational Cohort Study including 270 discharged patients with Covid-19. They will followed every four months with clinical and laboratory assessment until one year
Other
R00-R99
Sponsors
Faculdade de Medicina de Botucatu
Hospital Sírio-Libanês
Incor-HCFMUSP
Universidade Federal de Uberlândia
Escola Paulista de Medicina
Santa Casa de Araraquara
Hospital Estadual Américo Brasiliense
Hospital Estadual de Bauru
Hospital Beneficiência Portuguesa de Bauru
Faculdade de Medicina de Ribeirão Preto
Eligibility
Inclusion criteria
Inclusion criteria: Age over 18 years;presence of characteristic symptoms of the disease in an acute form of COVID-19 with positive test with needed of hospitalization;hypoxemia proved during hospitalization;chest computed tomography scan with pulmonary involvement during hospitalization and signing the informed consent form
Exclusion criteria
Exclusion criteria: Patients with other virus diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find variation in impairment of cardiopulmonary function through spirometry that can identify a drop in vital capacity and also in the volume of expiratory flow in the first second. Also through the diffusion of gases, we can identify reduced gas exchange as a complement to arterial blood gases. Finally, the six-minute walk test and the ergospirometry test can assess the maximum function of the cardiorespiratory system in subjects who were infected by covid-19;It is estimated that chest computed tomography is the tool capable of detecting pulmonary sequelae resulting from infection by Covid-19, which may be residual, persistent or progressive changes related to the covid-19 infection;It is estimated that by assessing the collected saliva, inflammation pathways can be assessed by metabolomic analysis in patients who were infected by covid-19 | — |
Secondary
| Measure | Time frame |
|---|---|
| It is estimated that through the application of quality of life questionnaires, the impact of emotional stress can be assessed for the impairment of acute illness during the recovery of patients who were infected with covid-19;It is estimated that through the sequential clinical laboratory evaluation it is possible to identify patients who have new diagnoses after hospital discharge, such as thromboembolic events, nutritional changes, changes in muscle function, renal changes in subjects who were hospitalized for covid-19;It is estimated that through echocardiographic evaluation it is possible to assess and monitor possible functional changes resulting from infection by covid-19 | — |
Countries
Brazil
Contacts
Public ContactAndre ;Eloara Alburquerque;Campos
Incor-HCFMUSP;Escola Paulista de Medicina
Outcome results
None listed