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Impact of Minimally Invasive Root Canal Treatment on Microbial Reduction, Postoperative Pain, and Regression of Endodontic Lesions in Lower Molars: A Randomized Controlled Clinical Study

Impact of Minimally Invasive Protocols on the Reduction of Intracanal Bacteria and Endotoxins, Postoperative Pain, and Periradicular Lesion Regression in Mandibular Molars: A Randomized Controlled Clinical Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-8j855ry
Enrollment
Unknown
Registered
2024-11-13
Start date
2023-12-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disinfection

Interventions

This is a randomized, parallel, superiority clinical trial with blinding. Experimental group: 30 mandibular molars with periradicular lesions will be treated using minimally invasive TruNatomy instrum
C07.320.830.700

Sponsors

Universidade do Estado do Rio de Janeiro - Faculdade de Odontologia
Lead Sponsor
Universidade do Grande Rio
Collaborator
Universidade do Estado do Rio de Janeiro - Faculdade de Odontologia
Collaborator

Eligibility

Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Healthy male or female patients between 18 and 60 years of age; with a lower molar presenting necrotic pulp and periradicular lesion, without prior endodontic treatment

Exclusion criteria

Exclusion criteria: Patients who have used analgesics in the past 12 hours or antibiotics in the past month; pregnant women; smokers; diabetics; those with an acute periapical abscess; periodontal pockets greater than 5mm; mobility greater than grade I; alveolar bone loss exceeding 50%; incomplete apices; teeth with calcifications and resorptions; and non-restorable teeth

Design outcomes

Primary

MeasureTime frame
Regression of periradicular lesion—

Secondary

MeasureTime frame
Reduction in microbial load in the root canal after endodontic treatment;Decrease in postoperative pain—

Countries

Brazil

Contacts

Public ContactAna Flávia Barbosa

Grande Rio University

anaflaviaabarbosa@gmail.com+55-21-28688287

Outcome results

None listed

Source: REBEC (via WHO ICTRP)