Coronavirus disease 2019
Conditions
Interventions
The prospective cohort of patients with suspected influenza-like illness (defined as the occurrence of fever and respiratory symptoms) and household contacts will undergo thorough clinical and laborat
2) adverse event in the instituted treatment
3) decompensation of an underlying disease
4) at the discretion of the study team (e.g., reassessment). On these unscheduled visits, in addition to the instruments defined for scheduled visits, a questionnaire will also be applied that contemp
Other
V03.175.500
E05.318.308.980.438
N02.278.065.200
Sponsors
Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)
Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)
Eligibility
Inclusion criteria
Inclusion criteria: Age equal to or greater than 18 years; Patients with fever and/or respiratory symptoms within 7 days; Contacts of patients with a flu-like syndrome
Exclusion criteria
Exclusion criteria: Patients who are unable to participate in study visits. Patients with severe mental disorders or those from whom the collection of information due to communication disorders or lack of fluency in Portuguese or another language understood by the attending physician is impossible.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| We expect to evaluate the natural history of the new coronavirus SARS-CoV-2 in Brazil | — |
Secondary
| Measure | Time frame |
|---|---|
| We expect to create serological and molecular panels to be used exclusively in public health action, using the samples of the biorepository;We expect to evaluate the performance and applicability of the RDT DPP ® COVID-19 IGM/IGG – Bio-Manguinhos rapid test, among others, for the diagnosis of the new Coronavirus SARS-CoV-2;We expect to design, through mathematical modeling, the number of patients, deaths, and number of beds needed in the states and in Brazil as a whole;We expect to identify which isolation measures are needed and for how long they are needed in the different states and in Brazil as a whole;We expect to develop a real-time model adjusted by mobility parameters, seasonality, and seroepidemiological surveys over time in different states and in Brazil as a whole;We expect to create a dashboard for managers and health departments with metrics and parameters used in the developed real-time model;We expect to describe the clinical manifestations of SARS-CoV-2 infection and its evolution in patients followed in different states of the Brazilian territory;We expect to investigate the risk factors and prognoses associated with severity, focusing on severe acute respiratory syndrome;We expect to correlate immunological, genetic and virological aspects with clinical manifestations and severity in patients with COVID-19;We expect to investigate the relationship between polymorphisms in human proteins that participate in the interaction with SARS-CoV-2 with susceptibility and clinical evolution of COVID-19;We expect to predict, from the use of machine learning techniques, patients who will evolve to the severe form of the disease;We expect to investigate the prevalence of active and previous infection in symptomatic and asymptomatic households contacts;We expect to determine the average incubation period and rate of infectivity in households contacts;We expect to analyze the phylogenetic relationship between viral isolates identified in Brazil with other countrie | — |
Countries
Brazil
Contacts
Public ContactJosé Moreira
Instituto Nacional de Infectologia Evandro Chagas/Fundacao Oswaldo Cruz (INI/Fiocruz)
Outcome results
None listed