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Effect of the application of previous ischemia on pain sensitivity and aerobic metabolism.

Effect of ischemic preconditioning on aerobic metabolism and pain sensitivity

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-8grbsz
Enrollment
Unknown
Registered
2018-07-11
Start date
2015-10-16
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Young Adult

Interventions

The study uses a randomized crossover approach. Thus, 20 subjects will perform a series of evaluations immediately, 1 h and 24 h after ischemic preconditioning and control treatment. The ischemic prec
Other

Sponsors

Centro de Ciências da Saúde e do Esporte - UDESC
Lead Sponsor
Centro de Ciências da Saúde e do Esporte - UDESC
Collaborator

Eligibility

Age
18 Years to 40 Years

Inclusion criteria

Inclusion criteria: Healthy volunteers; both sexes; non smokers; age between 18 and 40 years;

Exclusion criteria

Exclusion criteria: Regular use of any type of medication; smokers; osteo-articular lesion in the last twelve months;

Design outcomes

Primary

MeasureTime frame
Improvement in pain sensitivity, assessed by pressure pain threshold testing with expected increase of at least 10%. Data collected immediately before and after the intervention.;Improvement in pain sensitivity, assessed by the pressure pain threshold testing with an increase of approximately 27%. Data collected immediately before and after the intervention.

Secondary

MeasureTime frame
Improvement in pain sensitivity up to 24 h after treatment, evaluated by pressure pain threshold testing with expected increase of at least 10%. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.;Improvement in pain sensitivity up to 24 h after treatment, evaluated by the pressure pain threshold testing with increase of approximately 27%, 22% and 17% at 0 h, 1 h and 24 h after treatment, respectively. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.;Improvement in muscle blood flow up to 24 hours after treatment, evaluated by near infrared spectrophotometry with expected increase greater than 20%. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.;Improvement in muscle blood flow up to 1 h after treatment, evaluated by near infrared spectrophotometry with increase of 13.9% and 44.8% at 0 h and 1 h after treatment, but without significant increase at 24 h. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.;Improvement in mitochondrial function, assessed by near-infrared spectrophotometry with expected increase greater than 20%. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.;No significant change in mitochondrial function assessed by near infrared spectrophotometry. Data collected immediately before and 0 h, 1 h and 24 h after the intervention.

Countries

Brazil

Contacts

Public ContactFabrizio Caputo

Centro de Ciências da Saúde e do Esporte - UDESC

fabrizio.caputo@udesc.br+55-48-36648641

Outcome results

None listed

Source: REBEC (via WHO ICTRP)