Skip to content

Influence of periodontal treatment on microbiological, blood and salivary levels of Rankl, Survivin and Osteoprotegenin biomarkers in individuals with rheumatoid arthritis

Periodontal disease and rheumatic diseases: evaluation of clinical, immunological, genetic and microbiological associations. Subproject: rheumatoid arthritis and periodontal disease: association between periodontal treatment, oral microbiome and therapy with disease course modifiers

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-8g2bc8
Enrollment
Unknown
Registered
2020-04-09
Start date
2018-09-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid arthritis

Interventions

All one hundred and twenty-six individuals answered a structured questionnaire, containing personal data and the general health condition, questions related to the habit of oral hygiene and smoking. M
Procedure/surgery
C07.465.714.533

Sponsors

Faculdade de Odontologia da Universidade Federal de Minas Gerais
Lead Sponsor
Faculdade de Medicina da Universidade Federal de Minas Gerais
Collaborator

Eligibility

Age
35 Years to 65 Years

Inclusion criteria

Inclusion criteria: Volunteers with Rheumatoid Arthritis; both genders, aged 35 to 65 years; minimum period of 6 months from the last periodontal treatment; no use of antimicrobials in the period of 3 months prior to the study.

Exclusion criteria

Exclusion criteria: Volunteers diagnosed with other rheumatological diseases; diabetics; pregnant women; volunteers with disabling psychological or physical conditions.

Design outcomes

Primary

MeasureTime frame
Improvement in the periodontal condition, verified by full-mputj manual periodontal probing, from the finding of reduction of probing depth by at least 2mm, of gain of clinical attachment by at least 2mm, of reduction of the plaque index of at least 10 %

Secondary

MeasureTime frame
Decrease in periodontal bacterial levels, verified by real-time PCR, based on the finding of a reduction in the counts of A. actinomycetemcomitans, P. gingivalis, T. forsythia, Dental T in at least 10%;Improvement in the disease activity of rheumatoid arthritis, verified through the DAS-28 index, from the finding of a reduction in DAS-28 values by at least 2 points

Countries

Brazil

Contacts

Public ContactFernando Costa

Universidade Federal de Minas Gerais

focperio@uol.com.br+55 (31) 3409-2405

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 25, 2026