Chronic liver disease
Conditions
Interventions
All patients who agreed to participate in the study responded to a record containing identification data, age, gender, diagnosis of liver disease, respiratory symptoms, history, habits, MELD and calcu
diaphragmatic isometric exercise, Threshold IMT®
lifting upper limbs with bat and strengthening the abdominal.All exercises were performed in three sets, 15 reps. For training with Threshold IMT® a load 23-40 cmH2O was used adjusted for each patient
Device
Behavioural
E02.190.525.186
Sponsors
Faculdade de Ciências Médicas da Universidade Estadual de Campinas
Faculdade de Ciências Médicas da Universidade Estadual de Campinas
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: We included 37 patients who were on the waiting list for liver transplantation diagnosed with cirrhosis of any etiology; of both genders; over the age of 18; with or without the diagnosis of cardiorespiratory disorders associated with any value and MELD. These patients participated in the intervention group.
Exclusion criteria
Exclusion criteria: Patients who were unable to understand verbal commands due to the important encephalopathy were excluded; who failed to carry out evaluations; diagnosed with severe acute liver failure and those who were called to transplantation or patients participating in the intervention group who died.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proposed intervention was able to improve muscle strength of patients and consequently reduce the electrical activity of the diaphragm, as expected. Besides, there was as increased in functional capacity those who carried out the exercises. To compare proportions we used the chi-square test or Fisher's exact when needed. For comparison of numerical measurements between two groups we used the exact Mann-Whitney. For comparison of measures between groups and times was used ANOVA for repeated measures with transformation by posts. For comparison of changes in proportions, the McNemar.O test level of significance for statistical tests was p <0.05. The diaphragm RMS decreased in the intervention group (p = 0.001) and there was an increase of Functional Capacity score (p = 0.006, compared to the control group. ;There was a significant increase (p = 0.017) of MIP in the control group and intervention group after three months; and in the domains of the SF-36 General Health (p = 0.019) and Mental Health (p = 0.004). It was expected that there were only increased in the intervention group, however there was an increase in both groups after three months. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome expected and not found: it was expected that after three months patients in the control group who did not have ascites, presented ascites. We compared the presence of initial ascites with the presence of ascites after three months in the control group (p = 0.083) and intervention group (p = 0.31), no significant difference was found, as compared to the presence of ascites after three months between the groups (p = 0.21). ;Expected outcomes and that were found in the study: in the intervention group, patients with ascites at the end of time had worse scores on the Social Aspects domain of the SF-36 (p = 0.023) compared to those who had no ascites. In comparing the variables at the beginning and end of the study among former smokers or not, in the control group former smokers showed initial MEP (p = 0.047) and final (p = 0.009) higher than the smokers | — |
Countries
Brazil
Contacts
Public ContactVivian Limongi
Faculdade de Ciências Médicas da Universidade Estadual de Campinas
Outcome results
None listed