Nutritional disorders, Reproductive Physiological Phenomena, Sedentary Lifestyle, obesity, State of menopause and female climacteric.
Conditions
Interventions
The sample consists of seventy (70) women aged 50-79 years postmenopausal (no menstruation for at least twelve months), obese (body fat percentage> 33%), with a pattern of physical activity lower than
ii) Main - aerobic activities (50 minutes), and resistance / stretching (25 minutes)
and, iii) end (5 minutes) - activities back to calm.
Other
E02.779.483.750
E02.779.483.875
Sponsors
Universidade Estadual Paulista Júlio de Mesquita Filho de Presidente Prudente - SP
Universidade de Marília
Eligibility
Sex/Gender
Female
Age
50 Years to 79 Years
Inclusion criteria
Inclusion criteria: We included 70 women aged 50-79 years; postmenopausal (no period for at least twelve months); obese (fat percentage> 33%); previously sedentary (<150 minutes per week of moderate or vigorous physical activity in the past six months); all users of the Family Health Unit (USF); and no medical restrictions for physical exercise.
Exclusion criteria
Exclusion criteria: Introduced during the intervention health problems that limit or prevent the implementation of the exercise program; anyone associated with inflammatory responses such as influenza; diseases; recent surgical procedures; and acute arthritis condition; less than 65% frequency in the proposed interventions; not accomplish all assessment procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoint is represented by concentrations of interleukin-6 (IL-6). The IL-6 values are measured before and after the intervention period. The intervention will have 20 weeks, and will consist of physical exercise program with three weekly sessions of 25 minutes of exercise flexibility and strength, and 50 minute walk with intensity between 50-60% of VO2peak. The control group did not perform any kind of physical exercises. The concentration of IL-6 is determined by an immunoenzymatic ELISA Kit (BD Biosciences) at 2.2 pg / ml detection limit. To analyze the effects of the intervention on the IL-6 concentrations between the groups the ANOVA test will be applied for repeated measures (Split Plot), and adopted a 5% significance level.;IL-6 levels showed a significant reduction in both groups, control (3.41 ± 1.8 vs 2.41 ± 0.8; p = 0.006 *) and intervention (4.04 ± 2.6 vs 2 68 ± 1.0; p = 0.010). It was observed significant interaction between group and time of intervention (p = 0.546) after 20 weeks. The concentration of IL-6 was determined by an immunoenzymatic ELISA Kit (BD Biosciences) at 2.2 pg / ml detection limit. To analyze the effects of the intervention on the IL-6 concentrations between the groups the ANOVA test was used for repeated measures (Split Plot), and adopted a 5% significance level. significance of 5%. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are represented by TNF-alpha concentrations and interleukin-10 (IL-10). TNF-alpha and IL-10 will be measured before and after the intervention period. The intervention will have 20 weeks, and will consist of physical exercise program with three weekly sessions of 25 minutes of exercise flexibility and strength, and 50 minute walk with intensity between 50-60% of VO2peak. The control group did not perform any kind of physical exercises. The concentration of TNF-alpha and IL-10 is determined by an immunoenzymatic ELISA Kit (BD Biosciences) with 2.0 pg / ml detection limit. To analyze the effects of the intervention on the TNF-alpha and IL-10 concentrations between the groups the ANOVA test will be applied for repeated measures (Split Plot), and adopted a 5% significance level.;The IL-10 concentrations were significantly reduced in both groups, intervention (10.68 ± 3.6 vs 8.32 ± 2.4; p = 0.006) and control (14.27 ± 4.6 vs 8.78 ± 2.2; p = 0.0001). However it was observed significant interaction between group and time of intervention on the IL-10 levels (p = 0.015) after 20 weeks, indicating that the intervention group had lower magnitude reductions. The TNF-alpha concentrations were significantly reduced only in the intervention group (7.55 ± 5.0 vs 4.82 ± 3.6; p = 0.001), without significant changes in the control group (7.21 ± 5.3 vs 5.91 ± 5.8; p = 0.185). It was observed significant interaction between group and time of intervention on the TNF-alpha levels (p = 0.238) after 20 weeks. The concentration of TNF-alpha and IL-10 were determined by an immunoenzymatic ELISA Kit (BD Biosciences) with 2.0 pg / ml detection limit. To analyze the effects of the intervention on the concentrations of TNF-alpha and IL-10 between the groups the ANOVA test was used for repeated measures (Split Plot), and adopted a 5% significance level. significance of 5% .. | — |
Countries
Brazil
Contacts
Public ContactTeresa Zutin
Universidade de Marília
Outcome results
None listed