Evaluation of the implementation of a protocol to reduce the amount of blood collected in critically ill patients admitted to the intensive care unit after major surgery or in shock.

Feasibility Study of the Implementation of a Reduced-Volume Laboratory Blood Collection Protocol in Critically Ill Patients Undergoing Major Surgery or Shock.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-8f2t7ww

Enrollment

Registered

2026-02-27

Start date

2025-09-09

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Critical Care

Interventions

This is a randomized controlled clinical study with two parallel arms, open-label, with intention-to-treat analysis, conducted in an intensive care unit. A total of 50 adult participants were included

however, data analysis followed predefined objective criteria. In the control group, laboratory blood sampling performed through central venous catheters and arterial lines followed the institutional

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Age = 18 years; both sexes; admitted to the intensive care unit for postoperative care following major surgery or for shock requiring vasopressor use; with the presence of a central venous catheter and/or arterial access

Exclusion criteria

Exclusion criteria: Hemodynamic instability refractory to treatment; severe coagulopathy; severe anemia with hemoglobin lower than 7 grams per deciliter; hemoglobin decrease greater than or equal to 3 grams per deciliter within 24 hours

Design outcomes

Primary

Measure	Time frame
To assess the feasibility of implementing a reduced-volume laboratory blood collection protocol in an intensive care unit, verified through healthcare team adherence to the protocol and the occurrence of rejected samples or samples requiring recollection, with feasibility defined as protocol adherence greater than or equal to 80% and a low frequency of rejections or recollections related to operational errors	—

Measure

Time frame

To assess the feasibility of implementing a reduced-volume laboratory blood collection protocol in an intensive care unit, verified through healthcare team adherence to the protocol and the occurrence of rejected samples or samples requiring recollection, with feasibility defined as protocol adherence greater than or equal to 80% and a low frequency of rejections or recollections related to operational errors

—

Secondary

Measure	Time frame
To evaluate the impact of a reduced-volume laboratory blood collection protocol on the total volume of discarded and collected blood during intensive care unit stay, the need for sample recollection, variation in hemoglobin levels, and the requirement for red blood cell transfusion, assessed through comparison between control and intervention groups by analyzing absolute and relative differences in blood volumes, mean hemoglobin variation, and transfusion frequency during follow-up	—

Measure

Time frame

To evaluate the impact of a reduced-volume laboratory blood collection protocol on the total volume of discarded and collected blood during intensive care unit stay, the need for sample recollection, variation in hemoglobin levels, and the requirement for red blood cell transfusion, assessed through comparison between control and intervention groups by analyzing absolute and relative differences in blood volumes, mean hemoglobin variation, and transfusion frequency during follow-up

—

Countries

Brazil

Contacts

Public ContactMelissa Bhawmani Almeida

Unimed de Joinville Cooperativa de Trabalho Medico

melissaalmeidacti@gmail.com+55-85-999136848

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Mar 14, 2026