Cystic fibrosis Nutritional status
Conditions
Interventions
Intervention group : 20 patients with cystic fibrosis will receive follow-up guidance Mediterranean diet for 4 months .
Control group: 20 patients with cystic fibrosis will be guided to standard diet
Dietary supplement
Sponsors
Universidade Federal do Rio Grande do Sul
Hospital de Clínicas de Porto Alegre
Eligibility
Age
6 Years to 18 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with cystic fibrosis (n=40) confirmed by two tests dosage Na and Cl in the identification or sweat 2 mutations known to be related to illness and aged 6-18 years.
Exclusion criteria
Exclusion criteria: Patients with advanced lung disease (FEV1 < 40%); Patients using oral corticosteroids in the last two months and inability to perform pulmonary function tests.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction of the dosage of an inflammatory state in the period of 4 months , verified by C-reactive protein dosage and interleukin 1_B , 6, 8, 10 and 17 using a customized test the Multiplex based on the observation of a variation of at least 5 % in pre and post intervention measurements . | — |
Secondary
| Measure | Time frame |
|---|---|
| Increased lung function during the period of four months, verified by the analysis of FEV1 by spirometry from the realization of a range of at least 2% in pre and post intervention measurements. Increased quality of life in the period of four months, measured by questionnaire specific quality of life for FC from the realization of a range of at least 5% in pre and post intervention measurements. Improved fitness in the four months period measured by the walking test from the realization of a range of at least 5% in pre and post intervention measurements. Improvement in general evaluation parameters of the disease in the period of 4 months, as measured by the Shwachman-Kulczycki score from the realization of a range of at least 5% in pre and post intervention measurements. Reducing the frequency of pulmonary exacerbations in the period of four months, measured by the number of days with antibiotics from the realization of a range of at least 5% in pre and post intervention measurements. Increased antioxidant status in 4 month period measured by the dosage serum albumin Based on the observation of a variation of at least 5% in pre and post intervention measurements. | — |
Countries
Brazil
Contacts
Public ContactPaulo Maróstica
Hospital de Clínicas de Porto Alegre
Outcome results
None listed