Obesity
Conditions
Interventions
The interventions performed in the study based on dietary calorie restriction and probiotic supplementation. Probiotic supplementation will be performed using 1g sachets composed of a 1x109 CFU formul
2. Placebo group + 30% caloric restriction (GPLARC), totaling 15 individuals
Dietary supplement
Other
G07.203.300.456.500
Sponsors
Camila Guazzelli Marques
Departamento de Psicobiologia da Universidade Federal de São Paulo
Eligibility
Sex/Gender
Male
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: Male volunteers; sedentary; age between 20 to 40 years; body mass index (BMI) between 30.0 and 34.99kg / m2, which is obtained by dividing body weight, measured in kilograms, by the square height, measured in meters (kg / m2)
Exclusion criteria
Exclusion criteria: diabetics; vegetarians and vegans; accompanying with a nutritionist; performing any diet or food restriction; gastrointestinal surgery; using antibiotics in the last six months and anti-inflammatory drugs in the last fifteen days and the evaluation weeks; use of weight loss medications and/or antidepressants; use of drugs from the serotonin receptor family; regular consumption of probiotic/fermented products (kefir and kombucha); use of nutritional supplements (probiotics, prebiotics, symbiotics, multivitamins, omega-3, Whey Protein, and creatine); smokers; consumption of alcoholic beverages (> 30.0 grams of alcohol per week); regular physical exercise at least twice a week
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: to evaluate the reduction of fat tissue in obese individuals, determined by the assessment of body composition verified through the plestimography method at the beginning (baseline), middle (4th and 8th week) and end of the study (12th week) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary outcomes of the study consist of assessing changes in the composition and diversity of the intestinal microbiota, attenuating the metabolic endotoxemia process and, therefore, the systemic inflammatory processes, which will evaluate using laboratory tests and stool analysis methods performed at the beginning and end of the study | — |
Countries
Brazil
Contacts
Public ContactCamila ;Ronaldo Marques;Thomatieli dos Santos
Departamento de Psicobiologia da Universidade Federal de São Paulo;Departamento de Psicobiologia da Universidade Federal de São Paulo
Outcome results
None listed