Effectiveness and safety of at-home tooth Whitening: a clinical study

Efficacy and safety of DSP Home Tooth Whitening: A prospective, single-Blind, randomized study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

REBEC

Registry ID

RBR-8cq89mp

Enrollment

Unknown

Registered

2025-09-29

Start date

2025-09-30

Completion date

Unknown

Last updated

2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity

Interventions

This is a prospective, randomized, single-blind study (masked evaluator), which will be carried out at the Dental Clinics of UEPG (State University of Ponta Grossa). Patients will be recruited through

Group 2: 16% carbamide peroxide, 2 hours a day for 21 days

Group 3: 22% carbamide peroxide, 2 hours a day for 21 days. Group 4: 2% desensitizer for 10 minutes before bleaching, application of 10% carbamide peroxide, 2 hours a day for 21 days. Group 5: 2% dese

D27.720.642.315

Eligibility

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients of both sexes; aged 18 years or older; in good general and oral health; absence of carious lesions, restorations, and endodontic treatment in at least the six maxillary anterior teeth; right and left maxillary canines with shade A2 or darker, assessed by comparison with a value-oriented shade guide

Exclusion criteria

Exclusion criteria: Patients with dental prostheses; orthodontic appliances; pregnant or breastfeeding women; smokers; participants with a history of tooth whitening procedures; individuals with bruxism; gingival recession; dentin exposure; visible cracks in the teeth; history of dentin hypersensitivity; users of anti-inflammatory medications

Design outcomes

Primary

Measure	Time frame
All concentrations of carbamide peroxide (10%, 16% and 22%) are expected to provide satisfactory tooth whitening, with a significant improvement in tooth color (?E =3.0) and high patient satisfaction (OES scores =7/10). It is anticipated that prior use of the 2% desensitizer will effectively reduce the occurrence and intensity of dentin sensitivity during and after treatment. The results should prove the safety of the protocols, with a low incidence of adverse effects, maintaining whitening efficacy at all concentrations tested, thus offering safe and reliable alternatives for different clinical needs.	—

Measure

Time frame

All concentrations of carbamide peroxide (10%, 16% and 22%) are expected to provide satisfactory tooth whitening, with a significant improvement in tooth color (?E =3.0) and high patient satisfaction (OES scores =7/10). It is anticipated that prior use of the 2% desensitizer will effectively reduce the occurrence and intensity of dentin sensitivity during and after treatment. The results should prove the safety of the protocols, with a low incidence of adverse effects, maintaining whitening efficacy at all concentrations tested, thus offering safe and reliable alternatives for different clinical needs.

—

Secondary

Measure	Time frame
No secondary outcomes are expected.	—

Countries

Brazil

Contacts

Public ContactCleyson Crovador

Universidade Estadual de Ponta Grossa

cleysoncrovador@gmail.com+55(42)999317557

Outcome results

None listed

Source: REBEC (via WHO ICTRP)