hypertension
Conditions
Interventions
This is a crossover, double-blind, randomized controlled clinical trial. Approximately 20 volunteers were recruited to participate in the trial in a placebo crossover study. The volunteers ingested 10
Sponsors
Faculdade de Ciências Farmacêuticas da Universidade de São Paulo
Hospital Universitário da Universidade de São Paulo
Eligibility
Age
30 Years to 55 Years
Inclusion criteria
Inclusion criteria: Nutritional diagnosis of overweight and obesity grade 1 (Body Mass Index - BMI= 25-31 Kg/m2 and 25 to 29.9 Kg/m2); with cholesterol levels above 190 mg/dl; aged between 30 and 55 years; both genders
Exclusion criteria
Exclusion criteria: Previous history of cancer or severe metabolic diseases; digestive system disorders; smoking; allergy to passion fruit and fruit-based products; use of supplementation in the two months prior to the experiment (vitamin C, multivitamin, antioxidant capsules , etc.) or drugs for chronic treatments (antihypertensives, antihyperglycemics, anticholesterol, antidepressants, sleep aids, tranquilizers, etc.); acute treatments in the 15 days prior to the experiment (anti-inflammatories, antibiotics, etc. ); acute treatments in the two days prior to the experiment (inflammatory analgesics such as aspirin, acetaminophen, etc.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Considering that Passiflora tenuifila is rich in phenolic compounds, mainly proanthocyanidins and C-glycosylated flavones, and their absorption depends mainly on the action of the intestinal microbiota, the hypothesis of this project is that these phenolic compounds formed from the metabolization of P polyphenols .tenuifila by the microbiota may have local and systemic action on gene expression and production of inflammatory markers associated with cardiometabolic diseases. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are not expected | — |
Countries
Brazil
Contacts
Public ContactNeuza Hassimotto
Universidade de São Paulo
Outcome results
None listed