Leptospirosis
Conditions
Interventions
It's about a quasi-experimental cluster trial with 8 clusters to evaluate the efficacy of sanitation strategies with community engagement to reduce the incidence of Leptospira infection in Salvador, B
D000082463
Sponsors
Wellcome Trust
Instituto de Saúde Coletiva (ISC) - UFBA
Eligibility
Age
6 Months to No maximum
Inclusion criteria
Inclusion criteria: Sleeping =3 nights a week in a study household; They are =18 years old for leptospirosis study and between 0.6 month to 17 years to exploratory outcomes; living in the area for at least 6 months; understand and agree to participate in the study by signing the informed consent procedures. Participants who agree to use GPS for 24 hours in order to monitor their movements; signing a specific informed consent procedure.
Exclusion criteria
Exclusion criteria: Residents who being less than 18 years old (For the Leptospirosis study); residents that sleep less than 3 nights a week in a residence on site; residents who refuse or are unable to provide information, biological sample collection; residents who do not provide written informed consent to participate in the study; residents with limited mental health problems or other problems that have implications for survey responses or participation in any other phase of research activity; legal guardians who do not agree, in writing, with the participation of individuals under 18 years of age; residents with reduced mobility due to physical and mental conditions, which do not allow displacement to the neighborhood or other places in the community (previous or during the data collection period).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Aim 1: Prospectively evaluate the effectiveness of INT-ENG in reducing the risk of Leptospira infection. Primary outcome (Aim 1): Seroprevalence and incidence of Leptospira spp. using the microscopic agglutination test (MAT). 2) Aim 2: Determine mechanisms by which INT-ENG reduces direct human contact with sewage and the burden of environmental pathogens in urban slums. Primary outcome (Aim 2): Concentration of the leptospira in water or soil using quantitative real-time polymerase chain reaction (qPCR). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Evaluate the effectiveness of INT-ENG on the transmission of other urban health problems such as Arboviruses (Dengue, Zika and Chikungunya), Diarrhea (enteric diseases), Hepatitis A, Hantavirus, Toxoplasmosis and Covid-19, long-term infant development. 2) Evaluate the effectiveness of INT-ENG on improving preventive practices about infectious disease. 3) Evaluate the effectiveness of INT-ENG on improving well-being. 4) Evaluate the association between INT-ENG and Social cohesion (Engagement/participation). 5) Evaluate the perception of residents regarding INT-ENG and control. 6) Evaluate constructive and management aspects of INT. | — |
Countries
Brazil
Contacts
Public ContactFederico;Federico Costa.;Costa.
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Outcome results
None listed