Hypersensitivity
Conditions
Interventions
Experimental group: 20 patients with Class I malocclusion, of both genders who begin orthodontic treatment with metallic self-bonded brackets. Control group: 20 patients with Class I malocclusion, of
Device
Sponsors
Faculdade de Odontologia da Universidade Federal de Goiás
Faculdade de Odontologia da Universidade Federal de Goiás
Eligibility
Inclusion criteria
Inclusion criteria: Healthy volunteers; both genders; non smokers; Minimum age of 12 years, with Class I malocclusion, Angle; No previous orthodontic treatment; Without missing teeth; Without extensive metal restorations; No systemic diseases.
Exclusion criteria
Exclusion criteria: Patients who do not sign the free and informed consent; Patients on immunosuppressive drugs; Patients using drugs that involve hypersensitivity as antibiotics or ati-inflationary.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intra-oral reactions of nickel hypersensitivity in patients under corrective orthodontic treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase of urinary nickel levels evaluated by the Graphite Furnace Atomic Absorption Spectrophotometer before, after one month and after six months of treatment;Increased levels of salivary nickel measured by inductively coupled plasma mass spectrometry (ICP-MS) before, after one month and after six months of treatment;Increased pro-inflammatory Th1, Th2, and Th17 cytokine concentration as assessed by the sandwich-type immunoassay (CBA) before, after one month and after six months of treatment | — |
Countries
Brazil
Contacts
Public ContactMonarko de Azevedo
Faculdade de Odontologia da Universidade Federal de Goiás
Outcome results
None listed