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Pre-exercise blood flow restriction to minimize damage in the thigh muscles

Ischemic preconditioning to attenuate the magnitude of eccentric exercise-induced muscle damage in lower limb: a randomized, double-blind, placebo-controlled clinical trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-8brxg7
Enrollment
Unknown
Registered
2019-01-17
Start date
2018-12-20
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Musculoskeletal diseases

Interventions

This is a double-blind, placebo-controlled randomized clinical trial to be performed with 30 healthy young men with no recent experience with lower limb strength training, aged 18-35 years. Volunteers
Other

Sponsors

Universidade Federal do Rio Grande do Norte
Lead Sponsor
Universidade Federal do Rio Grande do Norte
Collaborator

Eligibility

Sex/Gender
Male
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Be a healthy male, aged 18-35 years and classified as irregularly active or active in the International Physical Activity Questionaire (IPAQ); Not being involved in strength training programs for lower limbs; not with a body mass index (BMI) of less than 18.5 kg / m-2 and greater than 30 kg / m-2; not be smokers or who use vasoactive medications and nutritional supplements regularly. Do not report musculoskeletal injury to lower limbs within 3 months prior to testing; not having uncontrolled diabetes mellitus or blood pressure; have no inflammatory rheumatologic condition or severe cardiovascular and / or pulmonary disease that prevents them from performing the evaluation and the proposed exercise; not having psychiatric disease and malignant tumors; not have presented Zika or Chikungunya in the last year.

Exclusion criteria

Exclusion criteria: Missing some day of collection; at any time and for any reason expressing an intention to leave the study; present a health problem that prevents them from continuing to participate in the research; use of medications, electrotherapeutic equipment or other therapeutic resources to improve pain and performance during the collection period; practicing unusual or strenuous physical activities during the days of collection.

Design outcomes

Primary

MeasureTime frame
Delayed-onset muscle soreness measured by the visual analogue pain scale (VAS) of 100 millimeters, where 0 is understood as no pain and 100 as the largest pain ever experienced by the volunteer.

Secondary

MeasureTime frame
Isometric torque measured by isokinetic dynamometer.;Range of motion of the knee measured by a goniometer.;Thigh circumference measured by perimetry;Serum creatine kinase levels measured from blood sample collection;Perception of discomfort during ischemic preconditioning and perceived exertion during eccentric exercise measured by the visual analogue scale (EVA) of the 0 a 100 mm and the Borg scale, respectively.

Countries

Brazil

Contacts

Public ContactMikhail Santos Cerqueira

Universidade Federal do Rio Grande do Norte

mikalsantosc@hotmail.com+55-084-3342-2018

Outcome results

None listed

Source: REBEC (via WHO ICTRP)