Rotator cuff lesions, adhesive capsulitis, glenohumeral instability and subacromial impingement.
Conditions
Interventions
Procedure/surgery
20 patients were randomly assigned using a computer-generated random number in a 1:1 relation. Control group: 10 patients were assigned to balanced general anesthesia (BGA). Experimental group: 10 pa
Sponsors
Instituto Nacional de Rehabilitación
Instituto Nacional de Rehabilitación
Eligibility
Age
35 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients scheduled for arthroscopic surgery of the shoulder; Patients of both genders; Patients from 35 to 70 years age Patients with American Society Anesthesiologists (ASA) physical status classification I or II; Patients who agree to participate in the study; Patients with leukocyte count within normal (count among 4 x 103/mm3 and 11 x 103/mm3)
Exclusion criteria
Exclusion criteria: Patients with obesity (body mass index higher 30 Kg/m2); Patients with malnutrition; diabetes mellitus; metabolic syndrome; pre-existing coagulopathy; acute or chronic focus of infection; congenital or acquired immunological disease; collagen disease; local or systemic inflammatory disease; endocrine disease; oncological disease; psychiatric illness; organ failure; chronic pain in another bodily region; use of steroids or immunomodulators; chronic use of non-steroidal anti-inflammatory drugs; chronic use of alpha2-adrenergic agonists; previous surgery of the same shoulder and airway difficulties.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| On the basis of previous studies of the influence of anesthetic techniques on the release of proinflammatory cytokines (TNF, IL-6 and IL-1) in several surgical procedures, a sample size calculation was made to compare paired measurements (one baseline and another after the intervention) in two study groups. The Sample Size Calculator of Statulator beta (http://statulator.com/SampleSize/ss2PM.html) was used taking the difference of the baseline and final IL-6 average in each study group (3.89) and the variance of the two differences (7.56), with a beta value of 0.80 and an alpha level of 0.05, estimating that at least 8 patients would be required to demonstrate statistically significant differences. By adding 20% of possible losses during the study, a final n of 10 patients was obtained for each study group. With a minimum of 8 hours fasting, quantification of Interleukin (IL) -1a, IL-1b, IL-1RA, IL-2, sIL-2RA, IL-6, IL-10, IL-12p40, IL-17, interferon gamma-induced protein 10 kDa (IP-10), monocyte chemoattractant protein (MCP) -1, macrophage inflammatory protein (MIP) -1a, MIP-1b, tumor necrosis factor (TNF) -a, vascular endothelial growth factor (VEGF) and eotaxin, erythrocyte sedimentation rate (ESR), high sensitivity C-reactive protein (CRP) and leukocyte concentration (WBC) from 9 ml of venous blood on three occasions: pre-anesthesia, immediate postoperative and 24 hours postoperative was performed for each patient.;ESR, CRP and leukocytes increased significantly at 24 h after surgery, however, the increase in ESR (p = 0.002) and CRP (p = 0.000) was lower in the SDIB group. There was a significant increase in sIL-2RA (p = 0.041) and IL-12p40 (p = 0.018) in the immediate postoperative period in the SDIB group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Presence and intensity of postoperative pain assessments were performed three times (immediate, 12 and 24 hours postoperative).;Immediate postoperative pain showed a significant increase (p = 0.000) in the BGA group. | — |
Countries
Mexico
Contacts
Public ContactGabriel Mejía-Terrazas
Hospital Ángeles México
Outcome results
None listed