Mild Cognitive Impairment
Conditions
Interventions
This is a randomized, controlled, double-blind clinical study with three experimental arms. The sample consisted of 90 elderly women with Mild Cognitive Impairment, randomly assigned to three groups,
G11.427.410.698.277
Sponsors
Universidade Federal de Sergipe
Universidade Federal de Sergipe
Eligibility
Sex/Gender
Female
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: The sample consisted of elderly women; aged between 60 and 80 years; physically independent and literate; who were not undergoing hormone replacement therapy and had a history of one year since their last menstruation; presenting a Montreal Cognitive Assessment (MoCA) score < 26; and who had subjective memory complaints (SMC); living near the institution and adjacent areas; free from neurological diseases (dementia; Parkinson's disease; Alzheimer's disease; multiple sclerosis; depression) or recent surgeries; vision problems (hyperopia; color blindness); hearing; musculoskeletal and cardiorespiratory problems that prevented the practice of high-intensity physical exercises
Exclusion criteria
Exclusion criteria: Attendance below 70%; absence from assessments; engaging in another type of physical activity practice at the same time as the intervention
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| As a primary outcome, an improvement in cognitive function is expected, determined by combining several subdomains, such as cognitive status, working memory, cognitive flexibility, semantic memory and executive function. These subdomains will be assessed through clinical tests, such as the Montreal Cognitive Assessment, Direct and Indirect Digit Count, and Categorical Verbal Fluency (number of animals and groupings), respectively. In addition, an increase in the peripheral concentration of brain-derived neurotrophic factor is expected after the intervention period, measured by an ELISA kit. These data provide evidence that cognitive function was improved after the intervention. Data were collected one week before and one week after the 4-month intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary outcome, positive adaptations in physical fitness are expected, which will be determined by the combination of physical adaptations, such as muscle power and strength, dynamic balance, upper limb mobility, walking speed, overall functionality and cardiorespiratory capacity. These adaptations will be assessed through physical tests, such as sitting and standing up in 5 repetitions, handgrip strength, timed up and go, putting on and taking off a shirt, walking 10 meters, gallons/getting up from the floor and walking for 6 minutes. These data provide evidence that physical fitness was improved after the intervention. Data collected one week before and one week after the 4-month intervention | — |
Countries
Brazil
Contacts
Public ContactSalviano Silva
Universidade Federal de Sergipe
Outcome results
None listed