Inflammatory Bowel Disease
Conditions
Interventions
This is a double-blind randomized clinical trial. The randomization process of the participants took place through the “runif” command of the “R” software (v. 4.1.3, The R Project Team, Vienna, Austri
All participants were instructed to take two capsules (500 mg, daily after lunch, for three months
Sponsors
Universidade Federal de Alagoas
Universidade Federal de Alagoas
Eligibility
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients diagnosed with IBD (Crohn's Disease, Ulcerative Colitis or Unclassified Colitis) of mild to moderate intensity; age equal to or greater than 18 years and up to 80 years; Patients using conventional drug therapy for IBD (aminosalicylates, immunosuppressants, biological); Function preserved kidney and liver
Exclusion criteria
Exclusion criteria: Pregnancy; Change or withdrawal of dosage/conventional medication for IBD; HIV positive patients and compromised renal and hepatic function; Patients who made inadequate use of supplementation (did not ingest the recommended daily dose)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1 - It is expected to find improved antioxidant activity (reduction of lipid peroxidation - malonaldehyde levels (MDA) and oxidized glutathione (GSSG) - increased antioxidant activity - superoxide dismutase (SOD), reduced glutathione (GSH), and reduced inflammatory activity (tumor necrosis factor alpha (TNF?) and interleukins (IL));Outcome found 1 - It was noticed that there were no changes in the inflammatory profile (fecal calprotectin, TNFa and IL) after supplementation with curcumin and curcumin+piperine. Regarding oxidative stress, the group supplemented with curcumin+piperine had an increase in SOD activity (p<0.05) compared to the placebo group. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2 - It was expected to find improvement in gastrointestinal complaints, such as nausea, vomiting, diarrhea, constipation, etc. | — |
Countries
Brazil
Contacts
Public ContactFabiana Moura
Universidade Federal de Alagoas
Outcome results
None listed