Skip to content

Effect of photodynamic therapy on gum treatment in patients with Down Syndrome

Evaluation of Antimicrobial Photodynamic Therapy as an adjunctive therapy to the treatment of Periodontitis in individuals with Down Syndrome: a randomized controlled clinical study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-899fry6
Enrollment
Unknown
Registered
2023-12-08
Start date
2021-01-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Down syndrome

Interventions

Patients will be allocated to two treatment groups using an online randomization system (www.sealedenvelope.com). The randomization of the groups will be carried out by an examiner, who will not treat
group SRP+aPDT (n=17) - SRP in a single session followed by irrigation of the bag with methylene blue (100 mg/mL) and after 60 seconds irradiation with an Aluminum Gallium Indium Phosphorus diode lase
660 ± 10 nm ) right after SRP
E02.186.500
E06.721.189.350

Sponsors

Faculdade de Odontologia de Araçatuba FOA
Lead Sponsor
Faculdade de Odontologia de Araçatuba FOA
Collaborator

Eligibility

Age
20 Years to 54 Years

Inclusion criteria

Inclusion criteria: Patients with diagnosis of periodontitis stages III and IV grade C according to the new classification with interproximal clinical attachment level (CAL) = 2 or = 3 mm in more than 2 non-adjacent teeth; Patients of both sexes; Who had not received periodontal treatment within 3 months with at least 2 sites with probing depth (PD) = 4mm and a minimum of 15 teeth present in the oral cavity, excluding third molars

Exclusion criteria

Exclusion criteria: Smokers or ex-smokers for more than 5 years; Patients with anemia; Patients with active cancer and history of chemotherapy; History of antibiotic therapy in the previous 3 months; History of anti-inflammatory therapy in the last 3 months; Patient with blood disorders; Patient undergoing orthodontic treatment; Patients who required prophylactic antibiotic therapy

Design outcomes

Primary

MeasureTime frame
Gain of Clinical attachment level 6 months after treatment, verified by periodontal probing, for the finding of 1mm variation of periodontal clinical insertion before and after intervention.

Secondary

MeasureTime frame
No secondary outcomes are expected.

Countries

Brazil

Contacts

Public ContactLetícia Theodoro

Faculdade de Odontologia de Araçatuba FOA

leticia.theodoro@unesp.br+55 (18) 3636-2860

Outcome results

None listed

Source: REBEC (via WHO ICTRP)