Skip to content

Effect of anti-inflammatory injection on the success of anesthesia in lower molar teeth in cases of toothache

Efficacy of submucosal Dexamethasone infiltration in anesthetic success in inferior alveolar nerve block, in cases of Symptomatic Irreversible Pulpitis in mandibular molars: a randomized clinical trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-89495pk
Enrollment
48
Registered
2026-04-22
Start date
2026-06-10
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pulpitis

Interventions

This study will involve 48 individuals randomly divided into two equal groups of 24 participants. To ensure proper randomization of participants, a table of random numbers will be generated using Rand

Sponsors

Universidade Federal do Rio Grande do Sul
Lead Sponsor
Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Individuals over 18 years of age of both sexes diagnosed with symptomatic irreversible pulpitis in the first or second mandibular molars; reporting moderate to intense pain at the time of initial assessment; with a score of 4 or higher on the Numerical Pain Scale (NPS); classified as healthy and immunocompetent according to the criteria of the American Society of Anesthesiologists (ASA); adapted for the dental clinic; who demonstrate full comprehension of the pain assessment scales and the informed consent form

Exclusion criteria

Exclusion criteria: Patients who after the start of the procedure decide or need to abandon treatment before the completion of the dental procedure

Design outcomes

Primary

MeasureTime frame
Assess pain relief using frequencies recorded on the visual analog scale after inferior alveolar nerve block with 2% Lidocaine combined with 1:100.000 epinephrine, with or without vestibular infiltration of dexamethasone corticosteroid solution

Secondary

MeasureTime frame
Based on the results of the visual analog scale analysis, describe using frequencies the need or lack thereof for supplemental anesthetic block using complementary techniques (intraligamentary or intrapulpal)

Countries

BR

Contacts

Public ContactMarcus Vinicius Só

Faculdade de Odontologia da Universidade Federal do Rio Grande do Sul

endo-so@hotmail.com+55(51)99967-8504

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: May 1, 2026