Parkinson disease
Conditions
Interventions
This is an open-label, randomized, controlled clinical trial involving individuals with Parkinson&apos
s disease experiencing freezing of gait (FoG), comprising four experimental groups and one control group. Unlike pharmacological studies, where the use of a placebo (inert pill) mimics the experience
s disease) will undergo High-Intensity Strength Training (HIST) and High-Intensity Strength Training (HIST) protocols, both in isolation and in combination with Immersive Virtual Reality (IVR), using
Sponsors
Universidade do Estado de Minas Gerais Unidade Divinópolis (UEMG Divinópolis)
Universidade Federal de Minas Gerais (UFMG)
Eligibility
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Male and female participants will be recruited, regardless of gender; classification in Hoehn and Yahr stages 1 to 4; self-reported episodes of freezing of gait (FoG) as assessed by the Freezing of Gait Questionnaire (FoG-Q); use of stable doses of antiparkinsonian medication for at least two months prior to and during the intervention; age between 18 and 85 years; absence of cardiovascular, musculoskeletal, vestibular, or other significant neurological disorders, confirmed by a medical report from the participant's attending physician; no participation in systematic high-intensity strength training programs in the last three months; and minimum cognitive status to complete the Hoehn and Yahr and FoG-Q questionnaires, as well as to provide informed consent regarding study participation
Exclusion criteria
Exclusion criteria: Participants who develop skin or scalp lesions at the electrode placement sites during data collection will be excluded. Additionally, volunteers with an adherence rate of less than 90% to the training sessions will be discontinued from the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected that motor test scores and functional questionnaires will reveal a significant enhancement in motor performance, accompanied by an optimization of electroencephalographic and electromyographic responses, as well as serum brain-derived neurotrophic factor (BDNF) concentrations. We hypothesize that these variations will reach statistical significance, with p-values falling below the established critical threshold, thereby confirming the efficacy of high-intensity resistance training on biomarkers and Freezing of Gait (FoG) symptoms in individuals with Parkinson’s Disease (PD) | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected that all intervention protocols will elicit statistically significant responses in electroencephalographic and electromyographic activity, as well as serum Brain-Derived Neurotrophic Factor (BDNF) concentrations, following an eight-week intervention involving individuals with Parkinson’s Disease (PD) and Freezing of Gait (FoG);It is expected that all intervention protocols will promote statistically significant improvements in motor test performance and maximum voluntary isometric contraction (MVIC) strength responses following an eight-week intervention involving individuals with Parkinson’s Disease (PD) and Freezing of Gait (FoG);It is expected that resistance training combined with Immersive Virtual Reality (IVR) and performed on weight machines will promote statistically significant optimizations in electroencephalographic and electromyographic responses, as well as in serum brain-derived neurotrophic factor (BDNF) concentrations, compared to other training protocols following an eight-week intervention involving individuals with Parkinson’s Disease (PD) and Freezing of Gait (FoG);It is estimated that resistance training combined with Immersive Virtual Reality (IVR) and performed on weight machines will elicit statistically significant increases in motor test performance and maximum voluntary isometric contraction (MVIC) compared to other protocols following an eight-week intervention involving individuals with Parkinson’s Disease (PD) and Freezing of Gait (FoG) | — |
Countries
BR
Contacts
Public ContactFrank Tourino
Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Outcome results
None listed