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Physiological effects of passive mobilization in critically ill patients admitted to the ICU

Hemodynamic effects, serum lactate levels and oxygen content of Passive Mobilization of lower limbs in patients under mechanical ventilation admitted to the Intensive Care Unit

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-87xznb
Enrollment
Unknown
Registered
2016-12-07
Start date
2016-05-22
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Intensive Care Unit, Monitoring, Physiologic

Interventions

Acute intervention study, with application of a protocol of passive mobilization of the lower limbs by the physiotherapist in 16 patients hospitalized in the ICU. Patients in dorsal decubitus with hea
Other
G07.700.560
M01.526.485.067.739

Sponsors

Sociedade Pelotense de Assistência e Cultura(SPAC)
Lead Sponsor
Hospital Universitário São Francisco de Paula
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: ICU patients; 18 years of age or over; both genders; under mechanical ventilation; with a degree of sedation equal to or greater than 4, measured by Ramsay scale; with central venous access (CVA); with prescription of motor physical therapy.

Exclusion criteria

Exclusion criteria: Patients with arterial access in the lower limbs; Grade 3 or 4 hypertonia, according to the Ashworth scale; Polytrauma or fractures not consolidated in the lower limbs; Patients in shock or infusion of high doses of vasoactive drugs; Patients with contraindication to bed elevation at 30 degrees or who did not tolerate the supine position.

Design outcomes

Primary

MeasureTime frame
Analysis of serum lactate, using the Lactate Gen.2 kit, in the COBAS INTEGRA, according to the technical standards of the Laboratory of Clinical Analysis (LEAC) of the São Francisco de Paula University Hospital. The hypothesis is that serum lactate will decrease 0.9 mg / dL after the early mobilization protocol.;The hypothesis was confirmed, with the pre-intervention lactate measurement of 15.41 (± 5.32) and post-14.44 (± 5.03), p value = 0.018.

Secondary

MeasureTime frame
Hemodynamic aspects, such as central venous saturation of O2, were determined based on the analysis of gasometry performed with Roche OMNI®S device, where no change was expected with the protocol. Heart rate and blood pressures were measured noninvasively by the multiparametric monitor, and a small increase, within the physiological limits, was expected for the greater venous return. As well as the respiratory rate obtained by the mechanical ventilator panel.;After the results, in relation to central saturation, the hypothesis was confirmed, with data pre - 71,84 (± 14,14) and post - 75,72 (± 9,19), there was no difference (p = 0.75) . Heart rate and mean blood pressure also confirmed hypotheses, with a significant increase in mean values of approximately 8 beats per minute (from 104.06 (± 25.29) to 112.81 (± 27.36), p = 0.007) and 10 mmHg (from 86.35 (± 11.28) to 95.83 (± 14.94), p <0.001) of the pre and post intervention measurement. The only outcome that did not confirm the hypothesis was the respiratory rate, which remained constant.

Countries

Brazil

Contacts

Public ContactRafael Orcy

Universidade Federal de Pelotas

rafaelorcy@gmail.com+55 (53) 3275-7335

Outcome results

None listed

Source: REBEC (via WHO ICTRP)