Vascular Diseases
Conditions
Interventions
The study will be randomized, parallel, double-blind and placebo-controlled. Volunteers will be randomly randomized, where the experimental group of 36 volunteers with vascular disease or diabetes mel
D01.248.497.158.606
I03.350
Sponsors
Universidade Federal do Rio de Janeiro Campus Macaé
Universidade Federal do Rio de Janeiro Campus Macaé
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Adults aged between 18-45; both sexes; physically active. Apparently healthy elderly people (over 60 years old); both sexes; eutrophic; physically active. unhealthy elderly (over 60 years old); both sexes; overweight; physically active; with the presence of one or more of the following clinical conditions: high triglycerides; high-density lipoprotein reduced cholesterol; increased waist circumference; high fasting blood sugar
Exclusion criteria
Exclusion criteria: Adults with cardiovascular diseases; inflammatory bowel diseases; lung disease; diabetes mellitus; hypertension; dyslipidemia; smoking; urinary infection; pregnant women; lactating women; using drugs that interfere with amino acid metabolism or nitric oxide production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; the presence of osteomioarticular lesions in 3 months; use of nutritional ergogenics; use of mouthwash. Apparently healthy elderly people without a diagnosis of cardiovascular disease, inflammatory bowel disease, lung disease, diabetes mellitus, hypertension, dyslipidemia and urinary tract infection; smoking; pregnant women, lactating women; using drugs that interfere with amino acid metabolism or NO production; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months. Unhealthy elderly people with any other pathology not previously described; use of antibiotics, anti-inflammatory; use of prebiotics, probiotics or synbiotics; use of nutritional ergogenics; use of mouthwash; the presence of osteomioarticular lesions in 3 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find, after long-term ingestion of a compound rich in nitrate and the practice of physical exercise, an improvement of the macro and microvascular endothelial function of the volunteers through the technique of flow-mediated dilation of the arteries; the improvement of performance parameters and muscle quality, through the isokinetic dynamometer and ultrasonography; increased angiogenesis and the modification of biochemical parameters and the composition of short-chain fatty acids in biological samples through analysis by gas chromatography | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find, after long-term ingestion of a nitrate-rich compound and physical exercise, the modification of body composition | — |
Countries
Brazil
Contacts
Public ContactThiago Alvares
Universidade Federal do Rio de Janeiro
Outcome results
None listed