Melasma
Conditions
Interventions
Intervention Group: 25 participants (women with facial melasma)
application of 0.2% isobutylamido thiazolyl resorcinol cream 5% cream on the melasma spots (topically) in two layers in the morning and two layers in the morning. During the day, colored facial sunscr
application of 4% hydroquinone in cream (topically) on the stains at night. During the day: application of colored facial sunscreen (guidance for reapplication every 3 hours) tinted facial sunscreen
Sponsors
Faculdade de Medicina de Botucatu (FMB - Unesp)
Escola Paulista de Medicina (EPM/UNIFESP)
Eligibility
Sex/Gender
Female
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: Women with facial melasma 18 to 50 years old, Fitzpatrick's phototypes II to V.
Exclusion criteria
Exclusion criteria: Pregnant and lactating women; women with vitiligo or photosensitizing diseases; individuals who are using other whitening substances and those who refuse to be photographed; photoexposed women and menopausal women (after 50 years).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluation of the severity of melasma assessed using the mMASI score (modified Melasma Area and Severity Index); evaluation at T30 (30th day) and T90 (90th day of treatment); a percentage reduction of at least 10% is expected in T90 compared to T0. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes will be evaluated through MELASQoL, dermatoscopy and clinical evaluation by the participant and the researcher, both at T0 and T60 and T90. | — |
Countries
Brazil
Contacts
Public ContactHelio Miot
Outcome results
None listed