Tenofovir
Conditions
Interventions
It is a prospective cohort study in which individuals will be observed through their time of using PrEP. Subjects will not be observed separately or receive any intervention. A hundred (100)individual
Other
Sponsors
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
Universidade Federal de São Paulo
Eligibility
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 18 years old or older; normal renal function by the beginning of the study protocol with estimated glomerular filtration ratio greater or equal to 90 mL/min; systolic blood pressure less or equal to 130 mmHg and diastolic blood pressure less or equal to 90 mmHg; no diagnosis of diabetes mellitus
Exclusion criteria
Exclusion criteria: to decide withdraw from this study; to present adverse renal events not related to PrEP use; diabetes mellitus diagnosis during the observational procotocol
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Appearance of laboratorial abnormalities within a year in blood analysis and urinalysis with one of the following criteria at least: normoglycemic glycosuria > 0,3 g/L, RBP (retinol=binding protein) > 40 mg/mL, proteinuria > 0,05 g/L, hematuria > 10 erythrocytes/hpf with dimorphism and albuminuria > 26 mg/g of creatinine. | — |
Secondary
| Measure | Time frame |
|---|---|
| Renal failure within a year in blood analysis with a rise by 1,5-1,9 times the baseline (before PrEP) creatinine. | — |
Countries
Brazil
Contacts
Public ContactDanilo Fernandes
Universidade Federal de São Paulo
Outcome results
None listed