Anxiety disorder, unspecified
Conditions
Interventions
A double-blind, randomized study was conducted, and the sample consisted of 72 patients hospitalized at the Restoration Hospital with zygomatic bone fracture and indication of surgical treatment under
Drug
E04.545
Sponsors
Universidade de Pernambuco
Universidade de Pernambuco
Hospital da Restauração
Eligibility
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Patients between 18 and 60 years of ag; ASA I and II; who had a unilateral fracture of the zygomatic bone; with a trauma time of less than 15 days; and who showed indication of surgical treatment with at least 2 access points and fixation.
Exclusion criteria
Exclusion criteria: Patients who do not fit the planning of surgical and anesthetic techniques; have fractures in other regions; need coronal access; use other medications in the postoperative period; or present allergy to study medications will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome 1: It is expected to improve the operative pain of patients who use melatonin through the use of transoperative opioids when compared to placebo, from the finding of a variation of at least 5% between groups.;Result Found 1: Patients using melatonin required less opioids compared to placebo (0.296 more or less 0.036 mcg/kg/ min vs. 0.372 more ou less 0.037 mcg/kg /min), with statistical difference from finding a variation of at minus 5% between groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome 2: It is expected to find an improvement in the sleep quality of the inpatients who use melatonin, evaluated using the Sleep Quality Rating Scale.;Result Found 2: In the sleep quality evaluation of the night before surgery, 61.1% of the patients in the Melatonin group reported better or much better sleep than usual, while 100% of the Placebo group reported worse sleep than or equal to usual (p less than 0.001). | — |
Countries
Brazil
Contacts
Public ContactEmerson Nogueira
Universidade de Pernambuco
Outcome results
None listed