Skip to content

Use of Medical Ozone Gas in Tooth Whitening: Evaluation of Results and Sensitivity

Evaluation of the Efficacy and Sensitivity of Dental Bleaching with Medical Ozone Gas Associated with Hydrogen Peroxide: A Randomized Clinical Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-877g8fj
Enrollment
120
Registered
2026-05-08
Start date
2026-02-01
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dentin Sensitivity Tooth Bleaching

Interventions

This is a randomized, controlled, and parallel clinical trial with two intervention arms. The study will include a total number of 120 participants, divided into four groups with 30 participants in ea
allocation. The procedures performed initially consist of prophylaxis with pumice and water for all patients. In the Control Group, a desensitizing agent will be applied for 10 minutes, followed by a

Sponsors

Colegiado de Odontologia
Lead Sponsor
Universidade Estadual do Oeste do Paraná
Collaborator

Eligibility

Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Patients of both sexes; age between 18 and 35 years; vital anterior teeth; teeth never bleached or restored; periodontal health; no history of spontaneous dental pain; non-use of desensitizing toothpaste; absence of dental cavitation; willingness to return for future evaluations during the research period

Exclusion criteria

Exclusion criteria: Smokers; pregnant or lactating women; participants with a history of dental sensitivity; presence of extensive restorations on anterior teeth; endodontically treated teeth; use of fixed orthodontic appliances; patients with periodontal problems; presence of caries or cracks in anterior teeth; continuous use of analgesics or anti-inflammatory drugs; participants with allergies to the components of the products used in the research

Design outcomes

Primary

MeasureTime frame
Primary outcomes include the evaluation of clinical efficacy and safety, measured by the magnitude of color change and the level of dentin sensitivity. The study will compare medicinal ozone gas alone against the conventional 35% hydrogen peroxide protocol, while also assessing ozone's potential to enhance bleaching and reduce sensitivity when used as an adjunct to 7.5% hydrogen peroxide.

Secondary

MeasureTime frame
The secondary outcome will analyze patient satisfaction regarding the procedure, focusing on aesthetic results and post-treatment comfort.

Countries

BR

Contacts

Public ContactMarcos Cocco Durigon

Universidade Estadual do Oeste do Paraná

marcos.cocco.durigon@gmail.com+55-55-999635146

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Jun 11, 2026