Malignant Hyperthermia
Conditions
Interventions
This is a longitudinal observational clinical study in patients with a personal or family history of malignant hyperthermia. In these patients, we will investigate the susceptibility to malignant hype
H01.158.273.343
Sponsors
Escola Paulista de Medicina da Universidade Federal de São Paulo
Setor de Hipertermia Maligna, EPM/UNIFESP
Eligibility
Age
14 Years to No maximum
Inclusion criteria
Inclusion criteria: History of susceptibility to malignant hyperthermia in the patient or first-degree relative, such as anesthetic malignant hyperthermia, intraoperative masseter hypertonia, neuroleptic malignant syndrome, exertional hyperthermia, exertion intolerance, idiopathic rhabdomyolysis, idiopathic elevation creatine phosphokinase, spontaneous masseter hypertonia and definitive myopathies or possibly associated with susceptibility to anesthetic malignant hyperthermia. Minimum interval of six months between the crisis suggestive of malignant hyperthermia and the muscle biopsy. Evaluation: all ages for clinical evaluation and 14 years for muscle biospsy; both sexes. Filling out the post-information consent form. Removal of a sufficient amount of muscle to carry out the muscle contracture test and the complete anatomopathological study. Positive muscle contracture test
Exclusion criteria
Exclusion criteria: Absence of history of susceptibility to malignant hyperthermia in the patient or first-degree relative
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find that patients with a personal or family history of malignant hyperthermia (MH) are susceptible to MH by the positive in vitro muscle contracture test defined by contracture with a threshold of 0.2 g. | — |
Secondary
| Measure | Time frame |
|---|---|
| No secondary outcomes are expected | — |
Countries
Brazil
Contacts
Public ContactMarcia Santos
Escola Paulista de Medicina da Universidade Federal de São Paulo
Outcome results
None listed