Rheumatoid arthritis, unspecified
Conditions
Interventions
Experimental condition: 20 participants will perform a single session of 30 min of treadmill aerobic exercise at 50% of the maximal aerobic capacity (VO2max).
Control condition: 20 participants will
Behavioural
G11.427.410.698.277
Sponsors
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HCFMUSP)
Faculdade de Medicina, Universidade de São Paulo
Eligibility
Sex/Gender
Female
Age
20 Years to 60 Years
Inclusion criteria
Inclusion criteria: Female sex; 20-60 years; hypertension; rheumatoid arthritis diagnosis; under usual care of the rheumatoid arthritis outpatient care at the Hospital das Clínicas of the Faculdade de Medicina of the Universidade de São Paulo.
Exclusion criteria
Exclusion criteria: Established cardiovascular and metabolic diseases; musculoskeletal problems that preclude the participation in exercise; ischemia or severe arrhythmias at rest or in the exercise test; class II obesity; use of medication that directly affect the autonomic nervous system (beta-blockers and non-dihidropiridin calcium blockers).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in resting blood pressure values, verified by an oscillometric device (Multiparametric monitor, MEC-1000, Shenzhen Mindray Bio-Medical Electronics Co), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control.;Reduction in the blood pressure response to the Strop Color-Word Test, verified by an oscillometric device (Multiparametric monitor, MEC-1000, Shenzhen Mindray Bio-Medical Electronics Co), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control.;Reduction in the blood pressure response to the Cold Pressor Test, verified by an oscillometric device (Multiparametric monitor, MEC-1000, Shenzhen Mindray Bio-Medical Electronics Co), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control. ;Reduction in the blood pressure response to the handgrip exercise with post-exercise circulatory occlusion, verified by an oscillometric device (Multiparametric monitor, MEC-1000, Shenzhen Mindray Bio-Medical Electronics Co), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control.;Reduction in the 24-h blood pressure, verified by an ambulatory blood pressure monitor that will be used for 24 hours, by means of a statistical significant variation between post-intervention and post-control. | — |
Secondary
| Measure | Time frame |
|---|---|
| Increase in heart rate at rest and in response to the Strop Color-Word Test, Cold Pressor Test, and Handgrip exercise, verified by a heart rate monitor (POLAR RS800cx, Kempele, Finland), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control.;Reduction in resting heart rate variability, verified by analyses in time- and frequency domain in the Kubios HRV® software (Biosignal Analysis and Medical Imaging Group, Kuopio, Finland), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control.;Increase in the resting blood flow in the brachial artery, verified by a Doppler ultrasound (Logiq E, General Electric, Milwaukee, USA) connected to a linear probe (12L-RS - 5.0–13.0 MHz), by means of a statistical significant variation between pre- and post-intervention and pre- and post-control. | — |
Countries
Brazil
Contacts
Public ContactTiago Peçanha
Faculdade de Medicina, Universidade de São Paulo
Outcome results
None listed