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Role of genetic variability and susceptibility in occupational exposure to anesthetics

Role of polymorphisms, genetic instability, oxidative response, expression and genetic methylation in occupational exposure to anesthetics

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
REBEC
Registry ID
RBR-864jjk
Enrollment
Unknown
Registered
2020-08-07
Start date
2015-09-04
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Occupational exposure to other air contaminants

Interventions

A group of 90 professionals working in the operating room and occupationally exposed to inhaled anesthetics will be observed for genetic variability and instability in comparison with 90 individuals n
Other
E01.370.225.998.110

Sponsors

Departamento de Anestesiologia
Lead Sponsor
Faculdade de Medicina de Botucatu (FMB)-UNESP
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Professionals working in the operating room; occupationally exposed to anesthetics; both genders and healthy individuals not exposed to inhaled anesthetics as participants in the control group

Exclusion criteria

Exclusion criteria: Malignant disease carriers; carriers of infectious or inflammatory diseases; those who regularly use alcohol; smokers; users of "illicit drugs"; those who use medication and / or vitamin supplementation; individuals exposed to radiation

Design outcomes

Primary

MeasureTime frame
We will test the hypothesis that occupational exposure to waste anesthetic gases (WAG) results in epigenetic modifications, specifically methylation, as well as genetic modifications due to changes in gene expression, and that polymorphisms influence the individual response to WAG toxicity.—

Secondary

MeasureTime frame
Are not expected.—

Countries

Brazil

Contacts

Public ContactMariane Silva

Faculdade de Medicina de Botucatu (FMB)-UNESP

maripereira1508@gmail.com+55-014-997660720

Outcome results

None listed

Source: REBEC (via WHO ICTRP)