Neoplasms of the Central Nervous System
Conditions
Interventions
For the intervention group, after anesthesia and before the beginning of the operative time, the patients will receive an initial dose of 15mg/kg of tranexamic acid, diluted in saline solution (0.9%)
Sponsors
Universidade Federal de São Paulo
Grupo de Apoio ao Adolescente e à Criança com Câncer
Eligibility
Age
No minimum to 18 Years
Inclusion criteria
Inclusion criteria: Patients from both genders; younger than 18 years old with a diagnosis of central nervous system tumor, characterized by radiological imaging (tomography or magnetic resonance imaging); whether it's their first surgery or reoperation due to relapse or progression; preoperative hemoglobin greater than 10mg/dl
Exclusion criteria
Exclusion criteria: Patients over 18 years of age; patients with tumors in sites other than the intracranial compartment; patients with a history of hematological, liver, kidney, vascular diseases or who have had a previous thromboembolic event; patients who refuse to participate voluntarily will be excluded from the study; patients with epilepsy refractory to anticonvulsant medication (defined as the presence of seizures in a period of less than 12 months in patients with at least two anticonvulsants in an optimized dose); patients with tumors with a volume greater than 50% of a cerebral hemisphere
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expect to find in this study the reduction of mortality and perioperative transfusion through the use of tranexamic acid in surgery of children with tumors of the central nervous system | — |
Secondary
| Measure | Time frame |
|---|---|
| Expect to find a reduction in intraoperative bleeding with the use of tranexamic acid in children undergoing resection of central nervous system tumors.;Expect to find a reduction in the use of intraoperative vasoactive drugs with the use of tranexamic acid in children undergoing resection of central nervous system tumors;We will observe the safety of the use of tranexamic acid through the surveillance of events such as seizures and thromboembolism in the first 7 postoperative days or until hospital discharge | — |
Countries
Brazil
Contacts
Public ContactMarcos Devanir da Costa
Grupo de Apoio ao Adolescente e à Criança com Câncer
Outcome results
None listed