Cardiovascular diseases
Conditions
Interventions
The 12 participants signed a Free and Informed Consent Form (ICF), in which information on research was described, including the guarantee of indemnity if something happens to the volunteer's health.
anthropometric: weight, height and waist circumference
clinical: blood pressure) and t3h (biochemical: glucose). and total triglycerides). The biological samples were collected from the volunteers by the Sabin partner laborator
Dietary supplement
Sponsors
Universidade de Brasília
INRA - Institut National de la Recherche Agronomique
Embrapa Cerrados
Eligibility
Sex/Gender
Male
Age
40 Years to 64 Years
Inclusion criteria
Inclusion criteria: Healthy subjects; males; aged between 40 and 64 years; overweight (BMI between 25 and 30 kg/m2 or waist circumference greater than 94cm).
Exclusion criteria
Exclusion criteria: Smokers; practitioners of physical activity over 5h per week; passion fruit allergic and fruit-based products; supplement users in the two months prior to the experiment (vitamin C, multivitamins, antioxidant capsules, etc.); medication users for chronic treatments (antihypertensive, antihyperglycemic, anticholesterol, antidepressant, sleep aid, anxiolytic, etc.), acute treatments in the 15 days prior to the experiment (potent anti-inflammatories, antibiotics, etc.); acute treatments in the two days prior to the experiment ( anti-inflammatory pain relievers such as aspirin, acetaminophen, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected Outcome 1: To evaluate the effect of Passiflora setacea juice on the modulation of certain inflammatory biochemical markers (glucose, triglycerides, HDL, PCR) by collecting blood from volunteers before and after each intervention.;Expected Outcome 2: To evaluate the effect of Passiflora setacea juice on modulation of certain immunological markers (pro and anti-inflammatory cytokines) in blood samples from volunteers by flow cytometry (CBA HUMAN TH1, TH2, TH17 Kit).;Expected Outcome 3: To evaluate the effect of Passiflora setacea juice on the modulation of the gene expression profile of the markers previously mentioned by microarray technique. | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome 1: Significant reduction in serum glucose and insulin concentrations after Passiflora setacea juice consumption.;Outcome 2: Significant reduction in serum IL-17A concentrations after Passiflora setacea juice consumption.;Outcome 3: Significantly reduced expression of 1327 genes associated with inflammation, metabolism, cell signaling, and neuronal function. | — |
Countries
Brazil
Contacts
Public ContactAna ;Isabella Costa;de Araújo Esteves Duarte
Embrapa Cerrados;Universidade de Brasília
Outcome results
None listed