Patients with cardiac disease who will undergo cardiac surgery
Conditions
Interventions
The patients wil be divided into 3 groups(n=30 in each). The groups will receive the medication 45 minutes prior to surgery. Midazolam group:midazolam 7,5 mg, orally. Morphine group: morphine 0,2 mg/k
Drug
Sponsors
Instituto de Cardiologia do Rio Grande do Sul
Ari Tadeu Lírio dos Santos
Eligibility
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients undergoing cardiac surgery with cardiopulmonary bypass; age of 18-65 years.
Exclusion criteria
Exclusion criteria: Non-elective surgery; weigh less than 50 or more than 100 kg; history of psychiatric disorder; ASA physics status of class IV; patients with a mental impairment, knowledge about allergy to studied drugs; patients with congenital cardiac disease and the patients that don't give informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The effect of midazolam, clonidine and morphine on the systolic arterial pressure in patients undergoing cardiac surgery, on arrival to operating room. On arrival to operating room will be measured the blood pressure (systolic) of patient. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effects of three drugs on level of sedation. Sedation will be evaluated by Ramsay Scale.;Effects of three drugs on level of anxiety. Anxiety will be measured by visual analog scale (VAS), on arrival to operating room.;Effects of three drugs on cardiac rate. Will be measured the cardiac rate on arrival to operating room.;Effects of three drugs on respiratory rate. The respiratory rate will be measured on arrival to operating room.;Effects of three drugs on oxygen saturation level. The arterial oxygen saturation level will be measured by pulse oximeter. ;Effects of three drugs on perception of pain caused by arterial and venous puncture. The pain perception will be evaluated by VAS.;Effects of three drugs on recall (amnésia). The amnésia will be evaluated by showing to patients 3 pictures and 3 words, printed on a card. At postoperative period, after awakening, the patients will be queried to recall of the pictures and words. | — |
Countries
Brazil
Contacts
Public ContactMaria Guedes
Comitê de Ética em Pesquisa
Outcome results
None listed