Post-traumatic stress disorder
Conditions
Interventions
Experimental group: 40 female adolescents victims of sexual violence, referred by the Pérola Byington Hospital, in São Paulo, and will be randomized after screening and first interview for Interperson
Sponsors
Universidade Federal de São Paulo
Columbia University
Eligibility
Sex/Gender
Female
Age
14 Years to 17 Years
Inclusion criteria
Inclusion criteria: Case: have been victims of sexual violence; age between 14 and 17 years; to have Post traumatic stress disorder (PTSD) diagnosis after the application of the Clinician administered PTSD scale for children and adolescents (CAPS CA) performed in the screening; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficit. Controls: did not present psychiatric diagnoses through the scale Schedule for Affective Disorders and Schizophrenia for School-Aged Children (K-SADS) , did not have a traumatic event of sexual violence through the CAPS-CA scale; do not present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; do not present decompensated clinical diseases that require intensive treatment; do not present significant intellectual deficits; absence of use of psychoactive substances in the last 6 months; not being pregnant; parents must be able to understand the informed consent term and the patient to understand, consent and sign the consent form for participation in the research; absence of intellectual deficits , intelligence coeficient( IQ)below 70.
Exclusion criteria
Exclusion criteria: Case: present psychiatric diagnoses prior to the traumatic event of sexual violence; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; Pregnancy detected through blood test.Controls: present psychiatric diagnoses; present a history of cranial trauma with diagnosed brain injury, treatment of epilepsy or neurosurgery; presenting with decompensated clinical diseases that require intensive treatment; present significant intellectual deficits; have a diagnosis of psychoactive substance dependence in the last 6 months; pregnancy detected through blood test; have been sexually abused.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patients victims of sexual violence under treatment (both with sandplay and with IPT - interpersonal psychoterapy ) may have structural brain changes (a decrease in the cortical thickness of the prefrontal cortex, the left insula, the left middle frontal gyrus, and a reduction in the volume of the tonsil) compared to healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Analyzes of functional magnetic resonance at rest, in the pre-treatment, may show decreased connectivity between the limbic regions and default mode network In addition, post-intervention analysis (both IPT - interpersonal psychoterapy and sandplay) may be associated with increased connectivity at rest, between limbic brain regions and the default mode network). Since measurements through magnetic resonance imaging pre and post treatment, could show hypoactivation of the default mode network, decreased connectivity between the right hippocampus and the posterior cingulate cortex.;Observe statistically significant effects (P lower than 0.05) of patients with PTSD(post traummatic stress disorder) presenting reduced fractional anisotropy in many white matter treatments when compared to controls (such as corona radiata, anterior and posterior portion of the internal capsule, genuine splenic corpus callosum, inferior longitudinal fascicle and uncinated issue). | — |
Countries
Brazil
Contacts
Public ContactAna Milani
Outcome results
None listed