Chronic Obstructive Pulmonary Disease
Conditions
Interventions
Each patient of a total of 21 participants will be subjected to two tests or interventions at rest and four cardiopulmonary exercise testing. The first test, at rest (randomized by simple draw) will b
Device
Other
C08.618.501
Sponsors
Universidade Federal de Mato Grosso do Sul
Universidade Federal de Mato Grosso do Sul
Eligibility
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: We will test 21 patients to reach a final eligible 7 patients with Chronic Obstructive Pulmonary Disease stage severe or very-severe and aged 40 to 75 years ; free of exacerbation for at least 2 months; on regular use of prescription drugs; should be able to perform spirometry and exercise testing; both gender; without important comorbidities like other chronic obstructive lung disease or cardiopathy; free of chronic domiciliar oxygen therapy
Exclusion criteria
Exclusion criteria: Patient with ischemic heart disease ; recent myocardial infarction; pulmonary arterial hypertension; uncontrolled systemic hypertension; diabetes mellitus or anemia ; furthermore can not participate in the study patients with severe aortic stenosis or musculoskeletal or rheumatic diseases and inability to use cycle ergometer for any reason
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Kinetics of oxygen consumption before and after intervention like time constant ; a monoexponential kinetics will be measured by analyzing the adjustment of oxygen consumption by measuring specific mathematical parameters such time constant, time delay and amplitude of the response; we expect to find an increase about 10% of the time constant and a reduction in amplitude of the same magnitude after tachypnea-induced hyperinflation and a reduction of the same magnitude for both after pre-exercise non invasive ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Exercise time after the intervention, set on a cycle ergometer at a load of 70 to 80% of the maximum load reached in the incremental test, measured in minutes; we expect to reach a increase of 10% of this time after deinflation of the lungs by non invasive ventilation and a decrease in average 10% of this time in the case of induced hyperventilation and hyperinflation | — |
Countries
Brazil
Contacts
Public ContactPaulo Müller
Universidade Federal de Mato Grosso do Sul
Outcome results
None listed