Respiratory failure
Conditions
Interventions
This is a randomized clinical trial with two arms, not blinded for outcome measurement. The study population will consist of men and women admitted to an intensive care unit, and who have undergone in
Sponsors
Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI
Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI
Eligibility
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Over 18 years of age; both genders; intubated patients; more than 24 hours on an invasive ventilatory system; tolerate spontaneous breathing test with Tayre connected to oxygen therapy support; arterial blood gases in stable state
Exclusion criteria
Exclusion criteria: Pregnancy; existing spinal cord injury; neurodegenerative diseases; need for emergency intubation; cardiac or respiratory arrest; facial and cranial trauma or surgery; tracheostomy; recent oral gastric or esophageal surgery; upper gastrointestinal bleeding; excessive amount of respiratory secretions; uncooperative patient; presence of hearing and vision deficits; patient who does not tolerate the spontaneous breathing test and previous medical decision to limit therapeutic effort
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of the study will be the incidence of adverse events associated with noninvasive ventilation, assessed by questionnaire. A higher incidence of adverse events is expected in the group receiving continuous and uninterrupted noninvasive ventilation | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of the effectiveness of noninvasive ventilation, considering the success rate of extubation and the reintubation rate in the first 48 hours. The same effectiveness is expected in both protocols, with better patient adherence to noninvasive ventilation in an interval manner; a better level of patient comfort, measured by the visual analogue scale. Total length of stay in the intensive care unit (days). Total length of hospital stay (days). In-hospital mortality rate (days). Blood gas analysis: hydrogen ion potential), partial pressure of oxygen, partial pressure of carbon dioxide and sodium bicarbonate before extubation, 1 hour after the installation of noninvasive ventilation and another hour after the withdrawal of noninvasive ventilation, at the end of both protocols. Hemodynamic data: peripheral oxygen saturation, systolic blood pressure, diastolic blood pressure, heart rate, respiratory rate before extubation, 1 hour after installation of non-invasive ventilation and another after removal of non-invasive ventilation, at the end of both protocols | — |
Countries
Brazil
Contacts
Public ContactEdina Steffens
Universidade Regional do Noroeste do Estado do Rio Grande do Sul - UNIJUI
Outcome results
None listed