Parkinson disease
Conditions
Interventions
Randomized clinical trial, 40 patients with Parkinson's disease aged 40-80 years with motor impairments related to hand function will be recruited and separated in four groups: aerobic training (AT),
the ST group will be used equipment for upper limb muscles with a volume of training of two series of 8 to 12 repetitions for each exercise with rest intervals of 2 minutes between the sets, and the i
G11.427.410.698.277
Sponsors
Laboratório de Neurociências - Universidade Federal de São Carlos
Harvard Medical School
Eligibility
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: The inclusion criteria will be age between 40 to 80 years; both genders; diagnosis of Parkinson's disease as confirmed by neurologist; stage 1-3 on the Hoeh and Yahr scale; who were not exercising at moderate intensity greater than 3 times per week within 3 months; complaints about motor impairments related to hand function (self-report); taking stable medications for Parkinson's disease for at least 30 days
Exclusion criteria
Exclusion criteria: The exclusion criteria will be features suggestive of other causes of parkinsonism/ Parkinson’s-plus syndromes, unstable medical conditions (e.g., uncontrolled diabetes, uncompensated cardiac issues, heart failure, uncompensated pulmonary disease, or chronic obstructive pulmonary disease), psychiatric diseases diagnosed by a psychiatrist; dementia (Mini-Mental State Examination score less than 24), presence of another neurological disorder and hearing or visual impairment
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome will be the Unified Parkinson’s Disease Rating Scale (UPDRS): motor function part III that is a comprehensive assessment designed to assess Parkinson's disease across the disease course and provide clinical endpoints in therapy trials. We hypothesized that there will be clinically relevant improvement after interventions compared to control. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary objective is evaluate the neuroplasticity effects of those interventions indexed by resting and task-related quantitative electroencephalography (motor execution, motor observation, and motor imagery). Our hypothesis is that there will be higher spectral power at high-frequencies bands (alpha and beta), and higher beta-ERS in the sensorimotor areas after exercise protocols compared with control groups; we hypothesized that electroencephalography changes will correlate with the upper limb function improvement indexed by UPDRS III.;The secondary outcome manual dexterity will be measured by the Nine-Hole Peg Test (9-HPT). We hypothesized that there will be clinically relevant improvement after interventions compared to control. | — |
Countries
Brazil, United States
Contacts
Public ContactMaryela de Menacho
Universidade Federal de São Carlos
Outcome results
None listed