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Comparison of treatment of platelet-rich plasma non-healing wounds in patients with venous abnormalities

Comparison of the treatment of chronic ulcers with platelet rich plasma in patients with venous insufficiency

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7zhgb3
Enrollment
Unknown
Registered
2019-12-17
Start date
2015-06-10
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Venous insufficiency

Interventions

Control group: 6 patients with venous insufficiency and chronic lower limb wound who received compression stocking (75 mmHg) and weekly care with dressing change and saline application
Experimental group: 6 patients with venous insufficiency and chronic lower limb wound using compression stockings and weekly care with dressing change and application of leukocyte-poor platelet-rich p
Biological/vaccine
D20.215

Sponsors

Universidade Estadual de Campinas
Lead Sponsor
Universidade Estadual de Campinas
Collaborator

Eligibility

Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: Diagnosis of chronic venous insufficiency; at most 80 years old and minimum of 18 years; ulcer with diameter 10 to 40 cm²

Exclusion criteria

Exclusion criteria: Exclusion criteria will be: base diseases of influence on healing, patients with malignant neoplasia in the last five years, lupus, carriers of ulcers neuropathic or arterial diseases, or any other type of ulcer in the lower limbs that is not related to chronic venous insufficiency; the patients who presented 3 (three) consecutive absences or 6 (six) alternate and the non-consent to participate in the research willingly and spontaneously, Uncontrolled Systemic Arterial Hypertension (SAH), Acquired Immunodeficiency Syndrome (HIV), Anemia, Stroke or Acute Myocardial Infarction (AMI) in the last 3 months, Renal insufficiency (creatinine more than 2 mg / dl), Liver Disease (TGO more than 2x upper limit, INR more than 1.5), surgery or major trauma in the last 2 months, pregnant woman, mental retardation, inclusion in other studies in the last 30 days and relative of first or second degree of another patient in the study group

Design outcomes

Primary

MeasureTime frame
Healing of chronic ulcers or reduction in size or quantity of wounds, verified by macroscopic evaluation of area measurement and photography—

Secondary

MeasureTime frame
Better quality of life and decreased pain for all patients assessed by venous disease-specific quality of life questionnaire—

Countries

Brazil

Contacts

Public ContactBeatriz Martinelli

Universidade Estadual de Campinas

beatrizm@unicamp.br1935218755

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: Feb 23, 2026