obesity
Conditions
Interventions
Control group: 22 overweight/obesity women with high body fat content will receive breakfasts daily for three months, containing a vitamin with soybean oil (25 ml) and differents cookies, breads and
Dietary supplement
SP6.051.227
Sponsors
Universidade Federal de Viçosa - UFV
Faculdade de Ciências Aplicadas da UNICAMP - Limeira
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: women; with 20 to 40 years old; overweight and with high body fat; basal energy requirements between 1200 to 1500kcal/day
Exclusion criteria
Exclusion criteria: presence of chronic diseases; weight and physical activity instability; use medication that affects some parameter assessed in the survey; smokers; pregnant or lactating; presence of eating disorders; presence of intestinal disorders; alcoholic.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in body composition, such as decreasing at least 2 kg of body weight, assessed by electronic weighing-machine and decreasing body fat content, assessed by densitometry by dual energy Xray absorptiometry (DEXA) after 3 months of coconut and olive oil consumption in comparison with soybean oil | — |
Secondary
| Measure | Time frame |
|---|---|
| Decrease of intestinal permeability assessed by evaluation of concentrations of urinary lactulose and mannitol and serum lipopolysaccharide. Increased feeling of satiety and reducing food intake, checked by applying visual analog scales (VAS) and 24 hours food records. Increased energy expenditure and the rate of lipid use as energy, verified by the measurement of energy expenditure and oxidation of energy substrates after consumption of breakfasts by open circuit indirect calorimetry. Improvement of blood biomarkers of metabolic syndrome (lipid profile,fasting glucose and insulin, uric acid and ketone bodies, C-reactive protein), systemic inflammation (TNF-alpha, IL-6, IL-1 b, IL-10) and oxidative stress (superoxide dismutase superoxide oxidase, catalase and plasma antioxidant capacity), verified by laboratory techniques involving colorimetric enzymatic methods and/or immunological assays. Change in intestinal microbiota composition, assessed by Fluorescende In Situ Hybridisation method (FISH). Decrease of genetic and molecular markers of fat cells formation and fat accumulation and changes in the form of fat cells checked by Real Time PCR and histochemistry. | — |
Countries
Brazil
Contacts
Public ContactFlávia;Flávia Cândido;Valente
Universidade Federal de Viçosa - UFV;Universidade Federal de Viçosa - UFV
Outcome results
None listed