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Efficacy of Bone Repair in Periapical Dental Lesions Using Different Methods: Platelet Aggregates with Autologous Platelet Rich Fibrin Membranes (L-PRF) Versus Bone Repair with Clot

Evaluation of Bone Repair After Periapical Surgeries Using Leukocyte Platelet-Rich Fibrin (L PRF) and Blood Clot: A Double-Blind Clinical Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7wc8dnw
Enrollment
Unknown
Registered
2022-03-08
Start date
2018-01-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Radicular Cyst

Interventions

This interventional study will be of the Randomized Clinical Trial type, as it is a prospective study to to compare the control group (clot) with the experimental group (LPRF), with 20 patients in eac
Cone-beam computed tomography (CBCT) prior to surgery
initial photograph of the region to be evaluated. The following procedures will be performed: Prior preparation
Antisepsis in the intraoral region will be performed with 0.12% chlorhexidine digluconate (Riohex Rioquímica) with mouthwash for 1 minute, and with the same product at 0.2% will be applied with smear
The anesthetic technique will be infiltrative in the area researched with 1 to 2 tubes of 1.8 ml (Mepiadre 2% with Epinephrine from DFL) and complemented with the infraorbital and nasopalatine nerve b
Incision with Lamina 15 in the Technique of Bilateral Oschsenbein-Luebke relaxation
Collection of the lesion with a Dentin curette 17/18 and packaged in glass containing 10% formaldehyde and sent for anatomopathological analysis by Puc Pr. 45° bevel cut made with the Zecrya drill num
Obturation o

Sponsors

Pontifícia Universidade Católica do Paraná
Lead Sponsor
Pontifícia Universidade Católica do Paraná
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: Presence of an apical lesion in an anterior maxillary tooth, well filled in the region surrounding the intracanal pin and with a prosthetic crown without infiltration and without any indication for removal, so that there is no risk of tooth fracture when the pin is removed; Patients that return with the active infectious process after root canal retreatment and that it is adequately shaped and filled.

Exclusion criteria

Exclusion criteria: As exclusion criteria: patients with systemic diseases such as diabetes mellitus blood dyscrasias, with thrombocytopenia below, 150,000 mm3

Design outcomes

Primary

MeasureTime frame
The results of this study showed a statistically significant difference in bone pocket repair when the L-PRF (Leukocyte Platelet Rich Fibrin) membrane was used in relation to the blood clot. There was a significant difference regarding the decrease in bone store volume after 90 days, both for the L-PRF(Leukocyte Platelet Rich Fibrin) membrane and for the blood clot. The group that used L-PRF (Leukocyte Platelet Rich Fibrin) was more effective in terms of bone repair, decreasing the size of the bone store in volume, than the group that used the blood clot, after 90 days, the decrease was 48.48% for the L-PRF(Leukocyte Platelet Rich Fibrin) and 29.26% for blood clot, and this percentage was also statistically significant.

Secondary

MeasureTime frame
Secondary outcomes are not expected.

Countries

Brazil

Contacts

Public ContactGil Gasparello

Pontifícia Universidade Católica do Paraná

gilguilhermeg@hotmail.com+55 41 3271-1555

Outcome results

None listed

Source: REBEC (via WHO ICTRP)