Effect of a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.

Effect of dietary monitoring based on a plant-based diet on vascular health, cardiometabolic risk factors, body composition, and muscle function.

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

REBEC

Registry ID

RBR-7w6pmpg

Enrollment

Registered

2026-03-31

Start date

2026-04-01

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular Disease

Interventions

This is a randomized controlled clinical trial with two parallel arms and single-blind design, in which 84 participants will be included, comprising adults (n = 42) and older adults (n = 42), allocate

Eligibility

Age

18 Years to 85 Years

Inclusion criteria

Inclusion criteria: Adults: age between 18 and 59 years; both sexes; physically active (more than 150 minutes per week of physical activity). Older adults: age equal to or greater than 60 years; both sexes; eutrophic (body mass index between 22 and 27 kg/m²); physically active (more than 150 minutes per week of physical activity)

Exclusion criteria

Exclusion criteria: Adults: decompensated cardiovascular diseases; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; pregnancy; lactation; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements, multivitamins, or pharmacological agents. Older adults: diagnosis of severe decompensated cardiovascular disease; uncontrolled diabetes; pulmonary disease; smoking; urinary infection; use of medications that interfere with amino acid metabolism or nitric oxide production; use of antibiotics or anti-inflammatory drugs; use of nutritional supplements or pharmacological agents

Design outcomes

Primary

Measure	Time frame
It is expected that after long-term nutritional monitoring, biochemical and hemodynamic parameters will significantly improve compared to the control group; and that the intervention group will show a more pronounced improvement in vascular health parameters, such as improved macro and microvascular endothelial function of volunteers through the flow-mediated dilation technique of arteries and arterial stiffness; improved parameters of muscle performance and quality, through isokinetic dynamometry and ultrasound; increased angiogenesis, plasma nitrate and nitrite, and improved body composition.	—

Measure

Time frame

It is expected that after long-term nutritional monitoring, biochemical and hemodynamic parameters will significantly improve compared to the control group; and that the intervention group will show a more pronounced improvement in vascular health parameters, such as improved macro and microvascular endothelial function of volunteers through the flow-mediated dilation technique of arteries and arterial stiffness; improved parameters of muscle performance and quality, through isokinetic dynamometry and ultrasound; increased angiogenesis, plasma nitrate and nitrite, and improved body composition.

—

Secondary

Measure	Time frame
It is expected that long-term nutritional monitoring will significantly improve body composition changes.	—

Countries

Contacts

Public ContactThiago Alvares

Universidade Federal do Rio de Janeiro Campus Macaé

alvares@macae.ufrj.br+55 (22) 21414091

Outcome results

None listed

Source: REBEC (via WHO ICTRP) · Data processed: May 1, 2026