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Tranexamic Acid in the Treatment of Melasma: A Comparative Study of the Efficacy of Chemical Peeling Versus Microneedling

Comparison of the Efficacy of Tranexamic Acid Peeling with Occlusion Versus Microneedling with Tranexamic Acid Solution for the Treatment of Melasma in Female Patients

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7tym97d
Enrollment
Unknown
Registered
2024-10-04
Start date
2023-07-01
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

melanosis

Interventions

A clinical trial will be conducted at the Aesthetic Health Teaching Laboratory of the State University of Ponta Grossa. The study will involve 30 female participants over the age of 18 with bilateral

Sponsors

Universidade Estadual de Ponta Grossa
Lead Sponsor
Universidade Estadual de Ponta Grossa
Collaborator

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Woman; bilateral facial melasma; over 18 years old; user of SPF 50 sunscreen every 4 hours

Exclusion criteria

Exclusion criteria: Patients under 18 years of age; pregnant and lactating women; patients on any therapy with warfarin, heparin, aspirin or any other anticoagulant medication; patients on vitamin E therapy; patient on hormone replacement therapy or photosensitizing drugs such as tetracycline, spironolactone , phenytoin and carbamazepine; patient with hypersensitivity to the formulations used in the study; patients with bleeding disorders; patient with skin changes such as facial warts, active/recurrent herpes simplex, dermatitis and/or seborrheic, atopic and eczematous dermatosis; patient with a history of keloids or hypertrophic scars; immunocompromised patients; oncology patients; patients with a history of use of oral or topical retinoids, oral tranexamic acid, dermabrasion, laser, surgery, topical bleaching agents, chemical peels performed on the face in the last 6 months

Design outcomes

Primary

MeasureTime frame
It is expected to find a better depigmenting effect on the side of the face treated with the peeling evaluated by the peeling and MAsi scale

Secondary

MeasureTime frame
No secondary outcomes are expected.

Countries

Brazil

Contacts

Public ContactPatrícia Boscardin

Universidade Estadual de Ponta Grossa

pdoll@uepg.br+55 (42) 32203120

Outcome results

None listed

Source: REBEC (via WHO ICTRP)