Remote Ischemic Preconditioning Intermittent Claudication Peripheral Arterial Disease
Conditions
Interventions
Fifty-two patients will be divided into three qrupos, respectively: A, B and C (control group).
In groups A and B will apply two tests on a treadmill with an interval of seven days between each test,
other
Sponsors
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
Eligibility
Inclusion criteria
Inclusion criteria: this study recruited patients complaining of typical intermitent claudication (IC) in one or both lower limbs, associated with absence or reduction of arterial pulses in the symptomatic member and/or ankle-brachial index < 0.90. Physical examination of the upper limbs was normal in all study participants.
Exclusion criteria
Exclusion criteria: Arterial occlusion of both upper Presence of critical ischemia of lower limbs, characterized by pain at rest or ischemic ulcerations existence of the same. Inability to perform the treadmill test for reasons other than the intermittent claudication, as changes rheumatologic, orthopedic, neurological, cardiac or respiratory Having used the following drugs in the last two hours before inclusion in the study: cilostazol, sildenafil, dipyridamole, glibenclamide, aminophylline, nicorandil, phenylephrine, angiotensin-converting enzyme inhibitors, angiotensin receptor blocker II, statins, alcohol, steroids, red wine. Having consumed a quantity of coffee that means a caffeine intake ? 4mg/kg (approximately 400 ml of coffee brewed in coffee maker) in the last two hours prior to study entry
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The final analysis will be performed to compare the initial walk distance and total walk distance, in traedmill, observed before and after ischemic preconditioning, with each patient his own control. | — |
Secondary
| Measure | Time frame |
|---|---|
| Also will be investigated a correlation between the variations found in the claudication distances and ankle - brachial index of the patients | — |
Countries
Brazil
Contacts
Public ContactNelson;GLAUCO Wolosker;SAES
Hospital Israelita Albert Einstein;Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo
Outcome results
None listed