Masseter muscle
Conditions
Interventions
Volunteers will be randomized into 2 groups: G1 (n=13) which will receive a single application of TxB-A on the masseter muscle bilaterally and at 3 months they will receive saline solution and G2 (n=
Sponsors
Faculdade Ingá - UNINGÁ/Paraná
Associação Brasileira de Odontologia- Secção Goiás
Eligibility
Sex/Gender
Female
Age
25 Years to 50 Years
Inclusion criteria
Inclusion criteria: Female patients; age between 25 and 50 years; complaining of enlargement of the lower third of the face; complaining of unilateral or bilateral hypertrophy of the masseter muscle; have not received aesthetic procedures on the lower third of the face in the last 12 months
Exclusion criteria
Exclusion criteria: Having received an anti-tetanus or COVID-19 vaccine within a period of less than three months, before starting the research; having previously received injections of botulinum toxin for aesthetic or therapeutic purposes; presenting autoimmune diseases; pregnant and lactating women; present neuromuscular diseases (Myasthenia gravis and Lambert-Eaton Syndrome); in current use of drugs that act on neuromuscular junctions; having performed cosmetic surgeries on the lower third of the face; missing teeth; individuals under 25 years of age; those who do not agree to sign the Free and Informed Consent Form; those who receive some type of vaccine during the research; received aesthetic procedures in the lower third of the face in the last 12 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| It is expected to find a reduction in the thickness of the masseter muscle over a period of three and six months, verified through ultrasound, based on a variation of at least 5% in pre and post intervention assessments.;It is expected to find a reduction in mandibular bone volume over a period of three and six months, verified through cone beam computed tomography, based on a variation of at least 5% in pre and post intervention assessments.;It is expected to find a reduction in the electrical activity of the masseter muscle over a period of three and six months, verified through surface electromyography based on a variation of at least 5% in pre and post intervention assessments. | — |
Secondary
| Measure | Time frame |
|---|---|
| It is expected to find a reduction in chewing performance over a period of three and six months, verified through the method of mixing two gums, based on a variation of at least 3% in the pre and post intervention assessments. | — |
Countries
Brazil
Contacts
Public ContactLuciana Machado
Faculdade Ingá - UNINGÁ/PR
Outcome results
None listed