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Effects of Aerobic Exercise with and without Cognitive Tasks on Gait control, Balance, Acetylcholine neurotransmitter Activity, activity of front part of the Brain and Symptoms of people with Parkinson´s disease

Effects of Resistance Training with and without Cognitive tasks on the Automaticity of Gait, Postural Instability, Cholinergic Activity, prefrontal cortex activity and Motor Symptoms Severity of individuals with Parkinson´s disease: A randomized double Blind study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7t8vqrz
Enrollment
Unknown
Registered
2022-02-14
Start date
2022-05-15
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Other anormalities of gait and mobility

Interventions

The 46 Participants will be divided into two groups: Endurance Training (ET) and Endurance Training plus cognitive Taks (ET+COG). Both with 23 participants. They will train three times a week for six
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Sponsors

Escola de Educação Física e Esporte da Universidade de São Paulo
Lead Sponsor
Escola de Educação Física e Esporte da Universidade de São Paulo
Collaborator

Eligibility

Age
50 Years to 85 Years

Inclusion criteria

Inclusion criteria: Parkinson´s disease severity at II-III stage according to the modified Hoen Yahr scale; Age between 50 and 85 years old; Global cognition with a score greater than 21 for individuals with schooling between 4 and 12 years, and greater than 20 for individuals with more than 12 years of schooling, according to the Monttreal Cognitive Assessment (MoCa), portuguese version; and being a faller (i.e., more than 2 falls in the last 6 months)

Exclusion criteria

Exclusion criteria: Not have had training in the last 6 months; No othe neurological disorder (beyond idiopathic Parkinson´s disease; Do not use AChE inhibitors (e.g., rivastigmine, donepezil, galantamine and tacrine), benzodiazepine, neuroleptic or tricyclic antidepressants; Not having resting tremor with a score greater than 2 (i.e., excessive tremor); and not present Freezing of Gait

Design outcomes

Primary

MeasureTime frame
Primary outcome- ET+COG will be more effective than ET alone in improving gait automaticity (our primary outcome) in people with Parkinson´s Disease (PD). Gait automaticity will be evaluated through the variability of gait parameters (most debilitating in PD) in a single task, but also in a dual task—

Secondary

MeasureTime frame
Secondary outcome- ET+COG will be more effective than ET alone in increase cholinergic activity (our principal secondary outcome) of people with Parkinson´s Disease. Cholinergic activity will be evaluated through Short Latency Afferent Inhibition, which is a paired pulse neurophysiological technique—

Countries

Brazil

Contacts

Public ContactJumes Lira

Escola de Educação Física e Esporte da Universidade de São Paulo

jumeslira@usp.br55 11 963596193

Outcome results

None listed

Source: REBEC (via WHO ICTRP)