Cicatrix
Conditions
Interventions
This is a randomized, controlled, double-blind clinical trial with two parallel arms, including a total of 24 participants (22 women and 2 men
mean age of 39.2 years). Participants were randomly assigned (1:1) into two groups:Experimental group (n = 12): Scars treated with microneedling using the MMP® technique combined with intradermal infu
Sponsors
Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais
Centro de Pós Graduação da Faculdade Ciências Médicas de Minas Gerais
Eligibility
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 70 years.Diagnosis of atrophic scars.Patients who provide their informed consent to participate in the study.Of both sexes
Exclusion criteria
Exclusion criteria: Patients who do not wish to have their data used in the study.Patients with malignant tumors.Patients who do not wish to have their data used in the study.Pregnant and breastfeeding women.Patients who are not taking contraception and have an active sex life at the time of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Expected outcome: we believe that there will be a significant improvement in the scars of patients treated with the microneedling method without administering microdoses of 5-FU.;Outcome found: The study confirmed that microneedling with microinfusion of saline solution was effective in the clinical improvement of hypochromic linear atrophic scars. Significant improvement was observed in parameters such as pigmentation, brightness, contour, and erythema, with increased subcutaneous tissue thickness and dermal remodeling documented by ultrasonography and histopathology | — |
Secondary
| Measure | Time frame |
|---|---|
| Expected outcome: We expect to see an improvement in patient satisfaction, improvement in skin pigmentation and texture and in skin atrophy.;Outcome found: There was significant improvement in all clinical parameters evaluated (pigmentation, brightness, contour, erythema) in both groups. Patient satisfaction was high, and blinded evaluators also assigned more favorable scores, especially in the group treated with saline solution. Histologically, dermal remodeling was observed with reorganization of collagen and elastic fibers, increased cellularity, and partial repigmentation in both groups | — |
Countries
Brazil
Contacts
Public ContactRaquel Campelo
Faculdade Ciências Médicas de Minas Gerais
Outcome results
None listed