Lack or loss of sexual desire
Conditions
Interventions
This is a randomized clinical trial involving women between 18 and 45 years old, complaining about low sexual desire. They will be randomized into two groups, with 25 patients in each group, and will
Drug
Sponsors
Universidade Federal de São Paulo - UNIFESP
Universidade Federal de São Paulo - UNIFESP
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Women over the age of 18 and the maximum age of 45 who are menstruating physiologically; decrease in sexual desire; sexual activity present with at least one sexual event per month and with current partner; be in good general health; being on contraceptive method (MAC); women over 40 years of age should have a clinically acceptable mammogram within the last 2 years;
Exclusion criteria
Exclusion criteria: Sexual dysfunction caused by another medical condition; body mass index (BMI) below 18 kg / m2 or above 35 kg / m2; undiagnosed genital bleeding; androgen therapy in the last 6 months (testosterone implant, testosterone transdermal cream, oral testosterone or injectable testosterone); antiandrogen therapy for acne or hirsutism in the last 5 years; moderate or severe acne, hirsutism, and androgenetic alopecia; participant with any hyperandrogenic syndrome; any clinical illness or severe depression, active cancer, or treatment of malignancy within the last six months; pregnancy or nursing; not attending our center for follow-up study visits
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Evaluate the improvement in quality of life after transdermal testosterone use in women with hypoactive sexual desire through a shortened quality of life questionnaire that will be applied before and after the use of a placebo or testosterone gel;Evaluate whether transdermal testosterone use in women with hypoactive sexual desire improved sexual complaints through a specific sexuality questionnaire (FSFI) applied before and after the transdermal gel;Evaluate in patients undergoing treatment with a history of depression whether there was improvement in depressive symptoms after medication use through the Beck questionnaire applied before and after the transdermal gel | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluate possible side effects of medications perceived in outpatient medical consultation after gel use | — |
Countries
Brazil
Contacts
Public ContactMarcela Margato
Universidade Federal de São Paulo - UNIFESP
Outcome results
None listed