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Influence of mechanical ventilation and heart rate on obstruction to cardiac blood flow in patients with hypertrophic obstructive cardiomyopathy

Influence of PEEP and heart rate on the maximum systolic gradient of the left ventricular outflow tract of patients with hypertrophic obstructive cardiomyopathy

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
REBEC
Registry ID
RBR-7rwmvj
Enrollment
Unknown
Registered
2018-09-11
Start date
2018-09-04
Completion date
Unknown
Last updated
2025-10-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertrophic obstructive cardiomyopathy

Interventions

Summary of interventions (data collection sheet attached): In this single-arm open-label trial, 16 patients diagnosed with hypertrophic obstructive cardiomyopathy and indication for endocardial radiof
Procedure/surgery
E02.041.625.790

Sponsors

Instituto Dante Pazzanese de Cardiologia
Lead Sponsor
Instituto Dante Pazzanese de Cardiologia
Collaborator

Eligibility

Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: All adult patients (> 18 years) diagnosed with hypertrophic obstructive cardiomyopathy, in follow-up at the cardiology outpatient clinics of the Dante Pazzanese Institute of Cardiology, with indication of septal reduction therapy, submitted to endocardial radiofrequency ablation of septal hypertrophy, who agree to participate in the study.

Exclusion criteria

Exclusion criteria: Patients who did not agree to participate in the study; Age under 18 years; Chronic obstructive pulmonary disease; Previous surgical myomectomy

Design outcomes

Primary

MeasureTime frame
To determine the influence of PEEP and heart rate on the maximum systolic gradient of the left ventricular outflow tract in patients with hypertrophic obstructive cardiomyopathy—

Secondary

MeasureTime frame
Correlate preoperative left ventricular outflow tract maximal gradients (at rest and during Valsalva maneuver) with intraoperative values (in the presence of different valeus of PEEP and heart rate);Determine adequate parameters of mechanical ventilation in patients with hypertrophic obstructive cardiomyopathy;Determine the impact of elevation of heart rate through atrial pacing in the hemodynamics of patients with hypertrophic obstructive cardiomyopathy;Evaluate the inhalation induction of anesthesia in patients with hypertrophic obstructive cardiomyopathy—

Countries

Brazil

Contacts

Public ContactBruno;Caetano Valdigem;Neto

Instituto Dante Pazzanese de Cardiologia;Instituto Dante Pazzanese de Cardiologia

valdigem@gmail.com;caenigro@uol.com.br+5511985060014;+5511983156024

Outcome results

None listed

Source: REBEC (via WHO ICTRP)